Abstract: Objective To explore the influence of mind mapping guided seamless nursing on nursing quality and satisfaction degree in operation room of department of urinary surgery. Methods Totally 80 patients with surgery in the department of urinary surgery were selected and randomly divided into observation group and control group, with 40 cases in each group. Routine operation management was carried out in the control group, and mind mapping guided seamless nursing was carried out in the observation group. The satisfaction degree to work, operation efficiency, management quality of operation room and nursing satisfaction degree were compared between two groups. Results In the observation group, the total satisfaction degree of the operating doctors were significantly higher than that in the control group, the operation preparation time and operation time of the patients were significantly shorter than those in the control group, the qualified rate of equipment sterilization, the correct rate of equipment inventory and the intact rate of first-aid materials were significantly higher than those in the control group, and the total satisfaction degree of the patients in the observation group were significantly higher than that in the control group(P<0.05). Conclusion Application of mind mapping guided seamless nursing in the operation room of department of urinary surgery can significantly improve the quality of nursing, increase doctor's satisfaction degree to nursing work in operating room, and improve the efficiency of operation.