Abstract: Objective To explore the risk factors of early neurological deterioration(END)in patients with acute ischemic stroke. Methods From August 2017 to February 2019, the materials of 193 patients with acute ischemic stroke in the Department of Neurology of Yizheng Hospital of Nanjing Drum Tower Hospital Group were collected and divided into END group(n=44)and non-END group(n=149)according to the incidence of early neurological deterioration. The general materials and clinical indexes in both groups were analyzed by one-way ANOVA and multivariate Logistic regression analysis. Results There were significant differences in National Institutes of Health Stroke Scale(NIHSS)score at hospital admission, systolic blood pressure at hospital admission, C reactive protein, continuous rise of C reactive protein, cholesterol, low density lipoprotein and homocysteine between the two groups(P<0.05). Multivariate Logistic regression analysis showed that the NIHSS score at hospital admission, systolic blood pressure at hospital admission, low density lipoprotein, homocysteine and continuous rise of C reactive protein or not were the independent influencing factors of END(P<0.05 or P<0.01). Conclusion The incidence of END in patients with acute ischemic stroke is closely related to the NIHSS score at hospital admission, systolic blood pressure at hospital admission, low density lipoprotein, homocysteine and continuous rise of C reactive protein.