高级检索

血浆同型半胱氨酸、血清25-羟维生素D3水平与青年糖尿病患者颈动脉内膜中层厚度的关系

刘艳丽, 钟义, 肖华蓉, 王宇宵

刘艳丽, 钟义, 肖华蓉, 王宇宵. 血浆同型半胱氨酸、血清25-羟维生素D3水平与青年糖尿病患者颈动脉内膜中层厚度的关系[J]. 实用临床医药杂志, 2020, 24(10): 45-48. DOI: 10.7619/jcmp.202010011
引用本文: 刘艳丽, 钟义, 肖华蓉, 王宇宵. 血浆同型半胱氨酸、血清25-羟维生素D3水平与青年糖尿病患者颈动脉内膜中层厚度的关系[J]. 实用临床医药杂志, 2020, 24(10): 45-48. DOI: 10.7619/jcmp.202010011
shu
LIU Yanli, ZHONG Yi, XIAO Huarong, WANG Yuxiao. Relationship between plasma homocysteine, serum 25-hydroxyvitamin D3 levels and carotid intima-media thickness in young diabetic patients[J]. Journal of Clinical Medicine in Practice, 2020, 24(10): 45-48. DOI: 10.7619/jcmp.202010011
Citation: LIU Yanli, ZHONG Yi, XIAO Huarong, WANG Yuxiao. Relationship between plasma homocysteine, serum 25-hydroxyvitamin D3 levels and carotid intima-media thickness in young diabetic patients[J]. Journal of Clinical Medicine in Practice, 2020, 24(10): 45-48. DOI: 10.7619/jcmp.202010011
shu

血浆同型半胱氨酸、血清25-羟维生素D3水平与青年糖尿病患者颈动脉内膜中层厚度的关系

  • 广东省韶关市铁路医院, 1. 内分泌科;

  • 2. 功能检查科;

  • 3. 检验科, 广东 韶关, 512023

详细信息

  • 中图分类号: R587.1

Relationship between plasma homocysteine, serum 25-hydroxyvitamin D3 levels and carotid intima-media thickness in young diabetic patients

  • 1. Department of Endocrinology;

  • 2. Functional Inspection Department;

  • 3. Laboratory Department, Shaoguan City Railway Hospital, Shaoguan, Guangdong, 512023

摘要

    摘要
  • 摘要: 目的 探讨血浆同型半胱氨酸(Hcy)、血清25-羟维生素D3［25-(OH)D3］水平与青年糖尿病患者颈动脉内膜中层厚度(CIMT)的关系。 方法 选取107例青年糖尿病患者作为研究对象,采用颈部血管超声测量CIMT,并依据CIMT值将患者分成3组,分别为重度增厚组(n=29)、轻度增厚组(n=33)以及未增厚组(n=45), 并选取107例同期体检的健康青年志愿者为对照组。检测所选受试者血浆Hcy和血清25-(OH)D3水平,观察各组患者Hcy和25-(OH)D3指标水平差异及其与CIMT的关系。 结果 重度增厚组、轻度增厚组和未增厚组患者血浆Hcy水平均显著高于对照组(P<0.05), 血清25-(OH)D3水平均显著低于对照组(P<0.05)。受试者CIMT与血浆Hcy水平呈正相关(r=0.463, P<0.001), 而与血清25-(OH)D3水平呈负相关(r=-0.339, P<0.001)。经Logistic回归分析,高水平血浆Hcy与低水平血清25-(OH)D3均是青年糖尿病患者CIMT增厚的独立危险因素(P<0.001)。 结论 青年糖尿病患者血浆Hcy与血清25-(OH)D3水平可在一定程度上反映CIMT状况,均可作为评价患者大血管病变发生风险的重要指标,为青年糖尿病患者的临床诊治提供指导。
    Abstract: Objective To study the relationship between plasma homocysteine(Hcy), serum 25-hydroxyvitamin D3(25-(OH)D3)levels and carotid intima-media thickness(CIMT)in young diabetic patients. Methods A total of 107 young diabetic patients were selected as research objects. CIMT was measured by neck vessels ultrasound, and these patients were divided into severe thickening group(n=29), mild thickening group(n=33)and thickening-free group(n=45)according to the values of CIMT, and 107 healthy volunteers in the same period with physical examinations were selected as control group. The plasma Hcy and serum 25-(OH)D3 levels were detected, and their differences in differed groups and their relationship with CIMT were observed. Results Severe thickening group, mild thickening group and thickening-free group had significantly higher plasma Hcy levels that the control group(P<0.05), and significantly lower serum 25-(OH)D3 levels than the control group(P<0.05). The subjects' CIMT had a positive correlation with plasma Hcy level(r=0.463, P<0.001), and a negative correlation with serum 25-(OH)D3 level(r=-0.339, P<0.001). Logistic regression analysis showed that high level of plasma Hcy and lower level of serum 25-(OH)D3 were both independent risk factors of CIMT thickening for young patients with diabetes(P<0.001). Conclusion The levels of plasma Hcy and serum 25-(OH)D3 in young diabetic patients can reflect the condition of CIMT to a certain extent, and can be used as important indicators to evaluate the risk of macro-vascular disease in young diabetic patients. Meanwhile, they provide guidance - for the diagnosis and treatment of these patients.
    • HTML全文
    • 参考文献(18)
  • 曹亚英, 孙可欣, 项骁, 等. 2型糖尿病患者血糖控制与颈动脉内膜中层厚度的相关性研究[J]. 中华疾病控制杂志, 2016, 20(7): 647-651.

    Durga J, Verhoef P, Bots M L, et al. Homocysteine and carotid intima-media thickness: a critical appraisal of the evidence[J]. Atherosclerosis, 2004, 176(1): 1-19.
    曲云霄, 蒋知新, 韩腾龙, 等. 血小板参数及活化标志物与2型糖尿病患者颈动脉内膜中层厚度的相关性[J]. 实用医学杂志, 2016, 32(8): 1250-1253.

    Wang M X, Sui J S, Wang S, et al. Correlations of carotid intima-media thickness with endothelial function and atherosclerosis degree in patients with type 2 diabetes mellitus[J]. Clin Hemorheol Microcirc, 2019, 72(4): 431-439.
    刘俊鹏, 刘勇. 老年2型糖尿病患者IL-18、CRP、CysC及APN与颈动脉内膜中层厚度的关系[J]. 中国老年学杂志, 2016, 36(3): 619-620.
    奴热姑·阿布都卡得, 徐新娟, 张俊仕, 等. 原发性高血压病患者1, 25二羟维生素D水平与颈动脉内膜中层厚度及中心动脉压的相关性研究[J]. 中国全科医学, 2018, 21(8): 914-918.

    Klobucníková K, Šiarnik P, Siváková M, et al. Carotid intima-media thickness is not associated with homocysteine and vitamin D levels in obstructive sleep apnea[J]. Scand J Clin Lab Investig, 2017, 77(4): 263-266.
    万芳. 血清25-羟维生素D3与老年糖尿病患者颈动脉内膜中层厚度的关系[J]. 中国老年学杂志, 2019, 39(23): 5677-5679.

    Kundi, Kiziltunc E, Ates I, et al. Association between plasma homocysteine levels and end-organ damage in newly diagnosed type 2 diabetes mellitus patients[J]. Endocr Res, 2017, 42(1): 36-41.
    刘溯, 杨宇红, 曹东华, 等. 不同水平25羟维生素D与老年糖尿病患者颈动脉IMT的相关性[J]. 实用临床医药杂志, 2015, 19(13): 30-32.
    陈荣浩, 周娟, 石春晖, 等. 糖尿病肾病患者25羟维生素D水平与颈动脉内膜中层厚度的相关性[J]. 中国老年学杂志, 2019, 39(11): 2617-2620.

    Basu A, Jenkins A J, Stoner J A, et al. Plasma total homocysteine and carotid intima-media thickness in type 1 diabetes: a prospective study[J]. Atherosclerosis, 2014, 236(1): 188-195.
    沈奇峰. 瑞舒伐他汀和阿托伐他汀对老年冠心病患者血脂、超敏C反应蛋白、同型半胱氨酸水平及颈动脉内膜中层厚度的影响[J]. 中国老年学杂志, 2017, 37(17): 4268-4270.

    Koluman B U, Mutluay R, Derici U B, et al. Association between osteoprotegerin, fetuin-A, carotid intima media thickness, and urinary albumin excretion in Type 2 diabetes[J]. Clin Nephrol, 2013, 80(1): 9-16.
    莫新玲, 杨锡恒, 谢婷, 等. H型高血压合并2型糖尿病患者血浆Hcy、Cyst-C水平与颈动脉内膜中层厚度的关系[J]. 广东医学, 2017, 38(6): 855-858.

    Aso Y, Okumura K, Takebayashi K, et al. Relationships of plasma interleukin-18 concentrations to hyperhomocysteinemia and carotid intimal-media wall thickness in patients with type 2 diabetes[J]. Diabetes Care, 2003, 26(9): 2622-2627.
    应长江, 周晓燕, 周冬梅, 等. 2型糖尿病患者血清护骨素与颈动脉内膜中层厚度的相关性[J]. 中国老年学杂志, 2017, 37(6): 1376-1378.

    Chen W J, Tian T, Wang S M, et al. Characteristics of carotid atherosclerosis in elderly patients with type 2 diabetes at different disease course, and the intervention by statins in very elderly patients[J]. J Diabetes Investig, 2018, 9(2): 389-395.
    • 相关文章
    • 施引文献
    • 资源附件(0)
计量
  • 文章访问数:  456
  • HTML全文浏览量:  64
  • PDF下载量:  9
  • 被引次数: 0
出版历程
  • 收稿日期:  2020-01-09
  • 网络出版日期:  2020-08-27

目录

摘要
HTML全文
    参考文献(18)
    相关文章
    施引文献
    资源附件(0)

    /

    返回文章
    返回

    © 2020 《实用临床医药杂志》编辑部

    地址：江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室邮编：225009电话：0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    本系统由 北京仁和汇智信息技术有限公司 开发  百度统计

    x 关闭 永久关闭