Abstract: Objective To analyze the effect of anti-reflux drugs administrated by diminishing method in treatment of patients with obstructive sleep apnea syndrome(OSAS)complicated with reflux esophagitis. Methods Totally 120 patients with OSAS and reflux esophagitis were selected and divided into conventional group(treated by conventional anti-reflux medication)and treatment group(treated by diminishing anti-reflux medication). The therapeutic effect, diagnosis score of gastroesophageal reflux disease, apnea hypopnea index, lethargy and artherial oxygen saturation were compared between the two groups. Results The total effective rate of the treatment group was significantly higher than that of the conventional group(P<0.05). After treatment, the diagnosis score of gastroesophageal reflux disease and apnea hypopnea index in the treatment group were significantly lower than those in the control group(P<0.05). After treatment, the score of lethargy in the treatment group was significantly lower than that in the conventional group, and the arterial oxygen saturation was significantly higher than that in the conventional group(P<0.05). Conclusion For OSAS patients with reflux esophagitis, the diminishing anti-reflux medication can effectively improve the symptoms and enhance the therapeutic effect.