Abstract: Objective To investigate the therapeutic effect of self-designed Tonifying Liver and Kidney Decoction and levodopa in combination for Parkinson's disease. Methods A total of 80 patients with Parkinson's disease were selected in the study, and were divided into control group and observation group according to admission order. The control group was given levodopa for treatment, and the observation group received self-made Tonifying Liver and Kidney Decoction based on the control group. The treatment conditions of the two groups were compared. Results There were no differences between the control group and the observation group in severity, anxiety and sleep conditions before treatment(P>0.05), while the Autonomic Nerve Symptom Scale for Parkinson's disease(SPOCA-AUT), Unified Parkinson's Disease Rating Scale(UPDRS)and Zung's Self-rating Anxiety Scale(SAS)scores of the observation group after treatment were lower than those in the control group, while the Parkinson's Disease Sleep Scale(PDSS)score was higher than that in the control group(P<0.05). The incidence of drug related adverse reactions in the observation group was significantly lower, and the quality of life score was significantly higher than that in the control group(P<0.05). Conclusion Self-designed Tonifying Liver and Kidney Decoction and levodopa in combination has good effect and high safety in the treatment of Parkinson's disease.