Research on levels of C reactive protein and homocysteine in elderly patients with dementia
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摘要: 目的 探讨老年痴呆患者的血清C反应蛋白(CRP)、同型半胱氨酸(Hcy)水平及其与痴呆程度的相关性。 方法 比较45例阿尔茨海默病(AD)患者(AD组)、35例血管性痴呆(VD)患者(VD组)和31名健康对照者(对照组)的血清CRP、Hcy水平。按照痴呆严重程度分为轻度痴呆组、中度痴呆组和重度痴呆组,比较不同程度痴呆组患者的CRP、Hcy水平。 结果 AD组、VD组CRP、Hcy水平显著高于对照组(P<0.01), VD组CRP、Hcy水平又显著高于AD组(P<0.01)。相关分析表明, AD组血清CRP水平与简易智力状态检查(MMSE)量表评分、年龄、痴呆严重程度均无显著相关性(P>0.05)。VD组血清CRP水平与MMSE评分呈显著负相关(r=-0.399, P=0.018), 与年龄呈显著正相关(r=0.426, P=0.011), 与痴呆严重程度无显著相关性(P>0.05)。AD组血Hcy水平与MMSE评分、痴呆严重程度呈显著负相关(r=-0.732、-0.721, P=0.001、0.001), 与年龄无显著相关性(r=-0.172, P=0.258)。VD组血清Hcy水平与MMSE评分、痴呆严重程度呈显著负相关(r=-0.402、-0.452, P=0.017、0.006), 与年龄无显著相关性(r=0.131, P=0.454)。轻度痴呆组(n=20)、中度痴呆组(n=49)、重度痴呆组(n=11)患者CRP、Hcy水平均显著高于对照组(P<0.01), 且中度痴呆组、重度痴呆组患者Hcy水平显著高于轻度痴呆组(P<0.01)。 结论 在老年痴呆患者中,检测血清CRP、Hcy水平有助于鉴别诊断AD和VD, 并且可能在判断痴呆患者病情进展和预后方面有一定的帮助。Abstract: Objective To explore the levels of serum C reactive protein(CRP)and homocysteine(Hcy)in elderly patients with dementia and their correlations with severity of dementia. Methods The serum CRP and Hcy levels were compared among AD group ［45 patients with Alzheimer's disease(AD)］, VD group ［35 patients with vascular dementia(VD)］ and control group(31 healthy controls). According to the severity of dementia, the patients were divided into mild dementia group, moderate dementia group and severe dementia group.The levels of CRP and Hcy in different groups were compared. Results The levels of CRP and Hcy in the AD group and the VD group were significantly higher than those in the control group(P<0.01), and the levels of CRP and Hcy in the VD group were significantly higher than those in the AD group(P<0.01). Correlation analysis showed that there were no significant correlations between CRP level and score of Mini-mental State Examination(MMSE)Scale, age and severity of dementia in the AD group(P>0.05). There was a significant negative correlation between serum CRP level and MMSE score in the VD group(r=-0.399, P=0.018), a significant positive correlation between CRP level and age(r= 0.426, P=0.011), but no significant correlation between CRP level and severity of dementia(P>0.05). In the AD group, the Hcy level was negatively correlated with MMSE score and severity of dementia(r=-0.732, -0.721, P=0.001, 0.001), but had no significant correlation with age(r=-0.172, P=0.258). In the VD group, the Hcy level was negatively correlated with MMSE score and severity of dementia(r=-0.402, -0.452, P=0.017, 0.006), but had no significant correlation with age(r=0.131, P=0.454). The levels of CRP and Hcy in mild dementia group(n=20), moderate dementia group(n=49)and severe - dementia group(n=11)were significantly higher than those in the control group(P<0.01), and the levels of Hcy in moderate dementia group and severe dementia group were significantly higher than that in mild dementia group(P<0.01). Conclusion In elderly patients with dementia, the detections of serum CRP and Hcy levels are helpful for the differential diagnosis of AD and VD, and may be helpful in judging the progression and prognosis of patients with dementia.
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Vishnu V Y, Modi M, Garg V K, et al. Role of inflammatory and hemostatic biomarkers in Alzheimer's and vascular dementia-A pilot study from a tertiary center in Northern India[J]. Asian J Psychiatr, 2017, 29: 59-62.
Cipollini V, Troili F, Giubilei F. Emerging biomarkers in vascular cognitive impairment and dementia: from pathophysiological pathways to clinical application[J]. Int J Mol Sci, 2019, 20(11): E2812-E2818.
Birkenhäger W H, Staessen J A. Convergence of atherosclerosis and Alzheimer's disease[J]. Lancet, 2004, 363(9426): 2091-2097.
Morgan A R, Touchard S, Leckey C, et al. Inflammatory biomarkers in Alzheimer's disease plasma[J]. Alzheimers Dement, 2019, 15(6): 776-787.
Lehmann D J, Cortina-Borja M. Genetic influence of plasma homocysteine on Alzheimer's disease[J]. Neurobiol Aging, 2019, 76: 217-218.
Nilsson K, Gustafson L, Hultberg B. C-reactive protein level is decreased in patients with Alzheimer's disease and related to cognitive function and survival time[J]. Clin Biochem, 2011, 44(14/15): 1205-1208.
Strang F, Scheichl A, Chen Y C, et al. Amyloid plaques dissociate pentameric to monomeric C-reactive protein: a novel pathomechanism driving cortical inflammation in Alzheimer's disease[J]. Brain Pathol, 2012, 22(3): 337-346.
Hsu P F, Pan W H, Yip B S, et al. C-reactive protein predicts incidence of dementia in an elderly Asian community cohort[J]. J Am Med Dir Assoc, 2017, 18(3): 277-288.
Ray L, Khemka V K, Behera P, et al. Serum homocysteine, dehydroepiandrosterone sulphate and lipoprotein(a)in Alzheimer's disease and vascular dementia[J]. Aging Dis, 2013, 4(2): 57-64.
Cervellati C, Romani A, Seripa D, et al. Oxidative balance, homocysteine, and uric acid levels in older patients with Late Onset Alzheimer's Disease or Vascular Dementia[J]. J Neurol Sci, 2014, 337(1/2): 156-161.
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