Abstract: Objective To compare the effect of gabapentin and carbamazepine in the treatment of patients with recurrent trigeminal neuralgia. Methods A total of 38 patients with recurrent trigeminal neuralgia were randomly divided into two groups, with 19 cases in each group. The observation group was treated with gabapentin, and the control group was treated with carbamazepine. The Visual Analogue Scale(VAS)and Life Satisfaction Index-B(LSI-B)were used to respectively evaluate the degree of pain and life satisfaction degree, and the total effective rate and the incidence of adverse reactions were compared between the two groups. Results After treatment, the LSI-B score of the observation group was significantly higher than that of the control group, and the VAS score was significantly lower than that of the control group(P<0.05). The total effective rate of the observation group was 94.74%, which was significantly higher than 84.21% of the control group(P<0.05). The incidence of adverse reactions was 26.32% in the observation group, which was significantly lower than 36.84% in the control group(P<0.05). Conclusion In the clinical treatment of patients with recurrent trigeminal neuralgia, the effect of gabapentin is significantly better than carbamazepine, which not only has a better therapeutic effect, but also has a lower incidence of adverse reactions.