Abstract: Objective To explore the effect of individualized evidence-based nursing on cognitive function in elderly patients with cerebral infarction. Methods A total of 110 elderly patients with cerebral infarction treated were selected and randomly divided into control group and study group according to random throwing method. The control group(n=55)implemented routine nursing, the research group(n=55)strengthened evidence-based individualized nursing. The National Institutes of Health Stroke Scale(NIHSS)score, Barthel Index score, and Modified Ashworth Scale of muscle tension(MAS)score, Fugl-Meyer Assessment for motor function(FMA)score, Mini-Mental State Examination(MMSE)score and nursing satisfaction between the two groups before and after nursing were compared. Results There were no significant differences in the NIHSS score, Barthel index score, MAS score, FMA score, and MMSE score between the two groups before nursing(P>0.05). The scores of NIHSS and MAS after nursing in the study group were lower than those of the control group(P<0.05); the Barthel index, FMA score and MMSE score after nursing in the study group were higher than those in the control group(P<0.05); the satisfaction of the study group was 96.36%, which was higher than 81.82% of the control group(P<0.05). Conclusion Evidence-based individualized nursing in elderly patients with cerebral infarction is effective, and it can improve patients'cognitive function and prognosis.