Abstract: Objective To compare the effect of open surgery and laparoscopic radical resection of cervical cancer in treatment of early cervical cancer. Methods A total of 80 patients with early cervical cancer were divided into two groups according to computer random grouping method, with 40 patients in each group. The control group received open surgery, and the observation group received laparoscopic radical resection of cervical cancer. The operative treatment conditions, resection area, postoperative recovery and complications were compared between the two groups. Results In the observation group, the intraoperative blood loss was(383.59±126.47)mL, which was less than(451.02±135.28)mL in the control group, and the operative time was(297.15±46.48)min, which was longer than(258.39±45.62)min in the control group(P<0.05). There were no significant differences between the two groups in the number of lymph nodes dissected, the length of left parastinal tissue resection, the length of vaginal resection, and the length of right parastinal tissue resection(P>0.05). The exhaust time and hospitalization time in the observation group was significantly shorter than those in the control group, and the hospitalization expenses was significantly higher than that in the control group(P<0.05). The incidence of complications in the observation group was 7.50%, which was lower than 27.50% in the control group(P<0.05). Conclusion Both open surgery and laparoscopic radical resection of cervical cancer in the treatment of early cervical cancer can effectively remove the focus, and there is no significant difference in the scope of resection, but the latter can effectively reduce surgical trauma, reduce the risk of complications, and promote early recovery.