Objective  To investigate the clinical efficacy and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of low-grade cervical squamous intraepithelial lesion (LSIL) patients with high-risk human papillomavirus (HR-HPV) infection.

  Methods  A total of 60 LSIL patients with HR-HPV infection were divided into control group and observation group according to random number table method, with 30 cases in each group. The control group was treated with routine medicine, while the observation group was treated with ALA-PDT. The treatment effects, the clearance rate of HPV, the scores of Self-rating Anxiety Scale(SAS) and Self-rating Depression Scale (SDS) were compared between the two groups.

  Results  Six months after treatment, the total effective rate of the observation group was 83.33%, which was significantly higher than 53.33% in the control group(P < 0.05). The clearance rate of HR-HPV in the observation group was significantly higher than that in the control group (P < 0.05). There were no significant differences in SAS and SDS scores between the two groups before treatment(P>0.05). After treatment, SAS and SDS scores in the observation group were significantly lower than those the control group(P < 0.05). No obvious adverse reactions occurred in the two groups.

  Conclusion  ALA-PDT is a safe and effective method in the treatment of LSIL with HR-HPV infection, and can improve status of anxiety and depression of patients.