Abstract: Objective To study effect of Qishen Yiqi Dropping Pills in improvement of cardiac function of heart failure patients. Methods A total of 200 patients with chronic heart failure were selected as research objects, and were divided into two groups according to their admission order. One hundred patients treated by Qishen Yiqi Dripping Pills were selected as observation group, and another one hundred patients treated by routine method were included in control group. The levels of N-terminal pro-brain natriuretic peptide(NT-proBNP), insulin-like growth factor 1(IGF-1), cardiac troponin T(cTnT), cardiac function indexes, therapeutic effect and Traditional Chinese Medicine syndrome score were compared between the two groups. Results After treatment, the levels of NT-proBNP, IGF-1 and cTnT showed significant differences in the two groups(P<0.05). There were statistical differences in cardiac function indexes in two groups(P<0.05). The total effective rate in the observation group was significantly higher than that in the control group(P<0.05). After treatment, the traditional Chinese medicine syndrome score was(1.21±1.03)in the observation group, which was significantly lower than(3.98±1.65)in the control group(P<0.05). Conclusion Qishen Yiqi Dropping Pills are of great significance in improving the cardiac function of chronic heart failure, and has higher safety.