Abstract: Objective To investigate the effect of amiodarone in adjuvant treatment of rapid atrial fibrillation with heart failure and its effect on cardiac function. Methods Ninety patients with rapid atrial fibrillation and heart failure were selected as research subjects, and were divided into control group and study group according to random number table method, with 45 patients in each group. Patients in the control group was given cedilanid, and those in the study group received cedilanid and amiodarone treatment. The clinical effects and adverse reactions of the two groups were compared, and the changes of left ventricular ejection fraction(LVEF), heart rate(HR), inflammatory factors ［tumor necrosis factor-α(TNF-α), interleukin-6(IL-6)and hypersensitive C reactive protein(hs-CRP)］ levels before and after treatment were compared. Results The total effective rate of clinical treatment in the study group was 95.56%, which was significantly higher than 77.78% in the control group(P<0.05). After treatment, the LVEF in the study group was significantly higher, HR in the study group was significantly lower than that in the control group(P<0.05). After treatment, the TNF-α, IL-6, and hs-CRP in the study group were significantly lower than those in the control group(P<0.05); there were no significant differences in the incidences of adverse reactions between the two groups(P>0.05). Conclusion Routine basic treatment combined with amiodarone can effectively improve cardiac function and inflammatory factors, and enhance the clinical treatment effect for patients with rapid atrial fibrillation combined with heart failure, and it has higher safety.