锌指核糖核酸结合蛋白在恶性肿瘤相关研究中的进展

Progress of zinc finger RNA binding protein in related researches on malignant tumors

  • 摘要: 锌指核糖核酸结合蛋白(ZFR)是一种古老的蛋白质。ZFR结构特殊,在原核生物中分布广泛。近年来, ZFR相关研究证实了ZFR是在各种恶性肿瘤中发挥作用的关键基因,其参与了恶性肿瘤的发生、进展和免疫应答等。在结直肠癌、肝细胞肝癌以及胰腺导管腺癌中, ZFR已经被鉴定为癌症候选驱动基因。本研究对ZFR与恶性肿瘤关系的相关研究进展进行综述,分析ZFR过表达在各类癌症的恶性进展和转移扩散中的作用机制。

     

    Abstract: Zinc finger RNA binding protein(ZFR)is an ancient protein. It has a special structure and is widely distributed in prokaryotes. In recent years, ZFR related studies have confirmed that ZFR is a key gene that plays a role in various malignant tumors, and is involved in the occurrence, progression and immune response of malignant tumors. ZFR has been identified as a candidate driver gene in colorectal cancer, hepatocellular carcinoma and pancreatic ductal adenocarcinoma. In this study, we reviewed the researches on the relationship between ZFR and malignant tumor, and analyzed the mechanism of over-expression of ZFR in the malignant progression, metastasis and diffusion of various types of cancers.

     

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