锌指核糖核酸结合蛋白在恶性肿瘤相关研究中的进展

朱晨辉; 金凤; 刘歆农

doi:10.7619/jcmp.202012034

锌指核糖核酸结合蛋白在恶性肿瘤相关研究中的进展

1. 扬州大学附属医院, 江苏扬州, 225009;
2. 扬州大学医学院, 江苏扬州, 225000

基金项目:

国家自然科学基金项目(81903850)

详细信息

通讯作者:
刘歆农,E-mail:yzyyxhk@163.com

中图分类号: R730.2
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- 文章访问数: 338
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出版历程
- 收稿日期: 2020-04-01

Progress of zinc finger RNA binding protein in related researches on malignant tumors

1. The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, 225009;
2. Medical College of Yangzhou University, Yangzhou, Jiangsu, 225000

摘要

摘要: 锌指核糖核酸结合蛋白(ZFR)是一种古老的蛋白质。ZFR结构特殊,在原核生物中分布广泛。近年来, ZFR相关研究证实了ZFR是在各种恶性肿瘤中发挥作用的关键基因,其参与了恶性肿瘤的发生、进展和免疫应答等。在结直肠癌、肝细胞肝癌以及胰腺导管腺癌中, ZFR已经被鉴定为癌症候选驱动基因。本研究对ZFR与恶性肿瘤关系的相关研究进展进行综述,分析ZFR过表达在各类癌症的恶性进展和转移扩散中的作用机制。
- 锌指核糖核酸结合蛋白 /
- 恶性肿瘤 /
- 免疫应答 /
- 结构域 /
- 肝癌环状非编码RNA /
- 抑癌基因
Abstract: Zinc finger RNA binding protein(ZFR)is an ancient protein. It has a special structure and is widely distributed in prokaryotes. In recent years, ZFR related studies have confirmed that ZFR is a key gene that plays a role in various malignant tumors, and is involved in the occurrence, progression and immune response of malignant tumors. ZFR has been identified as a candidate driver gene in colorectal cancer, hepatocellular carcinoma and pancreatic ductal adenocarcinoma. In this study, we reviewed the researches on the relationship between ZFR and malignant tumor, and analyzed the mechanism of over-expression of ZFR in the malignant progression, metastasis and diffusion of various types of cancers.
- zinc finger RNA binding protein /
- malignant tumors /
- immune response /
- domain /
- hepatocellular carcinoma circular non-coding RNA /
- tumor-suppressor gene

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参考文献(28)

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