Evaluation in effects of traditional Chinese medicine named Yufa Lotion in the treatment of androgenic alopecia
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摘要:目的 结合临床症状与毛发镜征象评价中药育发洗剂治疗雄激素性秃发（AGA）的疗效及安全性。方法 将56例AGA患者通过抽签方式随机分为观察组39例与对照组17例。观察组给予中药育发洗剂外用治疗，对照组给予空白洗剂外用治疗，2组患者均连续使用相应洗剂6个月。比较治疗前后3个固定观察区（额角、百会、发旋）毛发镜下的客观指标（总毛干数、毛干直径变异数量、毛干直径变异比值、头皮炎症）以及临床主观症状积分（头皮瘙痒、头皮油脂分泌、头皮屑），分析中药育发洗剂对AGA的治疗效果；比较2组不良反应发生率，评价中药育发洗剂治疗AGA的安全性。结果 治疗后，观察组左额角毛干直径变异比值、百会毛干直径变异数、百会毛干直径变异比值均低于治疗前，差异有统计学意义（P < 0.05）。治疗后，对照组左额角、百会、发旋部位的总毛干数、毛干直径变异数、毛干直径变异比值与治疗前比较，差异均无统计学意义（P>0.05）。治疗后，观察组头皮炎症和头皮瘙痒、头皮油脂分泌的治疗有效率均高于对照组，差异有统计学意义（P < 0.05）。2组患者治疗期间均未发生不良反应。结论 中药育发洗剂治疗AGA能减少毛干直径变异数量，降低毛干直径变异比值，显著改善头皮炎症、缓解瘙痒、减少头皮油脂分泌，且使用方便安全，无明显不良反应发生。Abstract:Objective To observe the efficacy and safety of traditional Chinese medicine named Yufa Lotion in the treatment of androgenic alopecia(AGA)by combining the clinical symptoms and trichoscopy system.Methods A total of 56 patients with AGA were randomly divided into observation group(n=39)and control group(n=17) according to lottery method. The observation group was given topical treatment with traditional Chinese medicine named Yufa Lotion, and the control group was given a blank lotion for external use. Both groups used the corresponding lotion continuously for 6 months. The objective indicators(total hair shaft count, hair shaft diameter variation, hair shaft diameter variation rate, scalp inflammation) under trichoscopy in three fixed observation areas (frontal angle, Baihui, and hairpin) before and after 3 months of treatment, clinical subjective symptoms integral (scalp itching, scalp oil secretion, dandruff) were compared, the therapeutic effects of traditional Chinese medicine named Yufa Lotion in the treatment of AGA were analyzed, and the safety of traditional Chinese medicine named Yufa Lotion in the treatment of AGA was evaluated. The incidence of adverse reactions of two groups was compared.Results After treatment, the observation group was significantly better than the control group in terms of variation ratio of hair shaft diameter in left frontal angle forehead, the number of hair shaft diameter variation in Baihui and the variation ratio of hair shaft diameter in Baihui of the observation group were significantly lower than before treatment (P < 0.05). The total number of hair shafts, the number of hair shaft diameter variations, and the hair shaft diameter variation ratio of the left frontal angle, Baihui, and hairpin showed no significant differences compared with those before treatment (P>0.05). After treatment, the effective rates of scalp inflammation, scalp itching and scalp oil secretion in the observation group were higher than those in the control group, and the differences were statistically significant (P < 0.05). There were no adverse reactions in the observation group and the control group during the treatment period.Conclusion The treatment of AGA with traditional Chinese medicine named Yufa Lotion can reduce the number of hair shaft diameter variation, decrease the hair shaft diameter variation ratio, significantly improve scalp inflammation, relieve itching, reduce scalp oil secretion. Besides, it is convenient and safe, and has no obvious adverse reactions.
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表 1 2组治疗前后毛发镜征象指标水平比较(x ±s)
组别 指标 左额角 百会 发旋 治疗前 治疗后 治疗前 治疗后 治疗前 治疗后 对照组(n=17) 毛干直径变异数/根 39.82±4.57 38.88±4.04 22.59±4.36 22.41±3.77 15.88±3.04 17.41±3.96 毛干总数/根 51.88±3.48 48.12±3.26 60.29±2.54 61.94±2.38 62.88±2.04 62.24±2.89 毛干直径变异比值 0.74±0.05 0.78±0.04 0.37±0.07 0.37±0.06 0.25±0.05 0.27±0.06 观察组(n=39) 毛干直径变异数/根 24.21±2.54 21.15±2.58 16.56±1.84 12.82±1.16* 12.54±1.18 12.67±1.36 毛干总数/根 38.92±2.28 39.90±2.17 53.21±1.98 54.31±2.20 56.23±1.97 59.08±2.73 毛干直径变异比值 0.58±0.04 0.49±0.05* 0.31±0.04 0.24±0.02* 0.22±0.02 0.21±0.02 与治疗前比较, *P < 0.05。 
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表 2 2组头皮炎症疗效比较[n(%)]
组别 治疗前后头皮炎症积分差 总有效 -2分 -1分 0分 1分 2分 对照组(n=17) 4(23.53) 3(17.65) 10(58.82) 0 0 10(58.82) 观察组(n=39) 0 4(10.26) 23(58.97) 11(28.21) 1(2.56) 35(89.74)* 与对照组比较, *P < 0.05。
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表 3 2组治疗后临床主观症状疗效比较[n(%)]
组别 症状 治疗前后临床主观症状积分差 总有效 -2分 -1分 0分 1分 2分 对照组(n=17) 头皮瘙痒 6(35.29) 6(35.29) 4(23.53) 1(5.88) 0 5(29.41) 头皮油脂分泌 4(23.53) 4(23.53) 9(52.94) 0 0 9(52.94) 头皮屑 5(29.41) 8(47.06) 3(17.65) 1(5.88) 0 4(23.53) 观察组(n=39) 头皮瘙痒 1(2.56) 4(10.26) 29(74.36) 5(12.82) 0 34(87.18)* 头皮油脂分泌 2(5.13) 10(25.64) 18(46.15) 9(23.08) 0 27(69.23)* 头皮屑 3(7.69) 26(66.67) 8(20.51) 2(5.13) 0 10(25.64) 与对照组比较, *P < 0.05。
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