Abstract: Objective To observe the clinical effect of amphotericin B aerosol inhalation combined with local perfusion and voriconazole in the treatment of invasive pulmonary fungal infections(IPFI). Methods A total of 80 patients with IPFI were selected and divided into control group and study group by simple random grouping method, with 40 cases in each group. The control group was given intravenous infusion of voriconazole, while the observation group was treated with aerosol inhalation of amphotericin B and local perfusion by fiberbronchoscopy on the basis of the control group. The clinical efficacy, treatment time and adverse reactions were compared between the two groups. Results The duration of treatment in the study group was(14.82±3.36)days, which was significantly shorter than(21.49±5.07)days in the control group(P< 0.05). The total effective rate in the study group was significantly higher than that of the control group(82.50%versus 60.00%, P<0.05). The total incidence of adverse reactions in the study group was lower than that in the control group, but the difference was not statistically significant(22.50% versus 32.50%, P>0.05). Conclusion Aerosol inhalation of amphotericin B combined with local perfusion plus voriconazole is safe and effective in the treatment of IPFI.