Effect of continuous positive airway pressure ventilation combined with ambroxol in treatment of neonatal respiratory distress syndrome
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摘要: 目的 观察持续气道正压通气联合氨溴索治疗新生儿呼吸窘迫综合征的疗效。 方法 将60例新生儿呼吸窘迫综合征患儿随机分为对照组和观察组,每组30例。所有患儿均予以生命体征监护、呼吸道管理、抗感染等基础治疗,对照组予以持续气道正压通气治疗,观察组在对照组基础上联合氨溴索治疗,比较2组治疗总有效率、氧合指数(OI)、氧疗时间和住院情况。 结果 观察组临床治疗总有效率为96.67%, 显著高于对照组73.33%(P<0.05); 观察组治疗24、48 h的OI均显著高于对照组(P<0.05); 观察组氧疗时间和住院时间均显著短于对照组(P<0.05); 观察组住院费用显著低于对照组(P<0.05)。 结论 呼吸窘迫综合征新生患儿可采用持续气道正压通气联合氨溴索方案进行临床治疗,疗效显著。Abstract: Objective To observe the effect of continuous positive airway pressure ventilation combined with ambroxol in treatment of neonatal respiratory distress syndrome. Methods A total of 60 cases of neonatal respiratory distress syndrome were randomly divided into control group and observation group, with 30 cases in each group. All children were given vital signs monitoring, respiratory management, anti-infection and other basic treatments, the control group was given continuous positive airway pressure ventilation treatment, and the observation group was combined with ambroxol treatment on the basis of the control group. The total effective rate, oxygenation index(OI), duration of oxygenation and hospitalization condition were compared between the two groups. Results The total effective rate of clinical treatment in the observation group was significantly higher than that in the control group(96.67%vs. 73.33%, P<0.05); the OI in the observation group was significantly higher than that in the control group at 24 and 48 hours after treatment(P<0.05); the duration of oxygen therapy and hospital stay in the observation group were significantly shorter than those in the control group(P<0.05); the hospitalization expenses in the observation group were significantly lower than those in the control group(P<0.05). Conclusion Continuous positive airway pressure combined with ambroxol regimen has significant efficacy for neonatal children with respiratory distress syndrome.
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