Abstract: Objective To compare the efficacy of levetiracetam and oxcarbazepine in the treatment of partial seizures in adults with epilepsy. Methods A total of 142 adult patients with partial seizures in adults with epilepsy were randomly divided into two groups according to computer randomized method, with 71 cases in each group. The control group was treated with levetiracetam and the observation group was treated with oxcarbazepine. The curative effect, electroencephalogram changes and adverse reaction rate before and after treatment were compared between the two groups. Results The total effective rate was 81.69% in the observation group, and 69.01% in the control group, but there was no significant difference(P>0.05). After treatment, the relative power of θ frequency band in the observation group was(30.76±6.84)%, which was significantly higher than(22.03±6.72)% in the control group(P<0.05). The ratio of patients with interictal epileptiform discharges(IEA)reducing more than 50% was 60.56% in the observation group, and was 54.93% in the control group, and there was no significant difference(P>0.05). The incidence of adverse reactions was 9.86% in the observation group, and 12.68% in the control group, but there was no significant difference(P>0.05). Conclusion Levetiracetam and oxcarbazepine are effective and safe in the treatment of partial seizures in adults, and can significantly inhibit IEA, but oxacepine has greater influence on activity of electroencephalogram.