Abstract: Objective To analyze the value of high-frequency ultrasound in the diagnosis of papillary thyroid carcinoma in children. Methods The clinical data of 150 children with papillary thyroid carcinoma confirmed by surgical pathological diagnosis was retrospectively analyzed. High-frequency color Doppler ultrasound and conventional two-dimensional ultrasound were separately given to these patients before surgery. Their coincidence rates of ultrasound were calculated and analyzed. Ultrasonographic features of children diagnosed by high-frequency color Doppler ultrasound were analyzed. Results The coincidence rate of high-frequency ultrasound examination was 70.00%, which was significantly higher than 54.00% of conventional two-dimensional ultrasoundexamination(P<0.05). The ultrasonographic findings were characterized by single nodule as main occurrence, rear echo attenuation, irregular morphology, unclear boundary, no sound halo, internal low echo, uneven echo, no cystic change, and more common occurrence of microcalcification, which showed significant differences when compared to the other items of ultrasonographic findings(P<0.05). Ultrasonographic findings of 150 papillary thyroid carcinoma showed that the proportion of children with blood flow distribution as grade 3 significantly exceeded those with grade 1 and grade 2(P<0.05). Out of 150 children with papillary thyroid carcinoma, there were 28 cases(18.67%)complicating with lymphadenectasis, and a low echo, no lymphatics, and slight calcification showed significant differences(P<0.05). Conclusion High-frequency color Doppler ultrasound is of certain value in diagnosis of children with papillary thyroid carcinoma. Combined with two-dimensional ultrasound, it can clarify the characteristics of the tumors and provide a basis for surgical treatment.