Abstract: Objective To explore the application value of invasive mechanical ventilation at different time points in treatment of patients with chronic obstructive pulmonary disease combined with severe respiratory failure. Methods A total of 60 invasive mechanical ventilation patients with chronic obstructive pulmonary disease combined with severe respiratory failure were selected as research objects, and were divided into control group and observation group according to the order of admission. The patients in the control group(n=30)were given invasive mechanical ventilation after 6 h of indications for mechanical ventilation, the patients in the observation group(n=30)were given early(6 h)invasive mechanical ventilation therapy, treatment effect of two groups was compared. Results The duration of mechanical ventilation and hospitalization time in the observation group were shorter, the incidence of complications was lower, and the score of quality of life was higher than that in the control group(P<0.05). There were no differences in blood gas indexes between the two groups before treatment(P>0.05). After treatment, arterial partial pressure of oxygen and oxygenation index of the observation group were higher, and arterial partial pressure of carbon dioxide was lower than that of the control group(P<0.05). Conclusion Invasive mechanical ventilation therapy for patients with acute attack of chronic obstructive pulmonary disease complicated with severe respiratory failure can improve the blood gas indexes, reduce the incidence of complications, shorten the duration of mechanical ventilation and hospital stay, and improve the quality of life of the patients.-