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柴胡龙骨牡蛎汤联合抗抑郁药治疗脑卒中后抑郁的效果观察

赵玺灵, 张留, 唐星, 宋虎杰, 余春

赵玺灵, 张留, 唐星, 宋虎杰, 余春. 柴胡龙骨牡蛎汤联合抗抑郁药治疗脑卒中后抑郁的效果观察[J]. 实用临床医药杂志, 2020, 24(17): 58-61. DOI: 10.7619/jcmp.202017015
引用本文: 赵玺灵, 张留, 唐星, 宋虎杰, 余春. 柴胡龙骨牡蛎汤联合抗抑郁药治疗脑卒中后抑郁的效果观察[J]. 实用临床医药杂志, 2020, 24(17): 58-61. DOI: 10.7619/jcmp.202017015
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ZHAO Xiling, ZHANG Liu, TANG Xing, SONG Hujie, YU Chun. Effect of Chaihu Longgu Muli Decoction combined with anti-depressant in treating patients with post-stroke depression[J]. Journal of Clinical Medicine in Practice, 2020, 24(17): 58-61. DOI: 10.7619/jcmp.202017015
Citation: ZHAO Xiling, ZHANG Liu, TANG Xing, SONG Hujie, YU Chun. Effect of Chaihu Longgu Muli Decoction combined with anti-depressant in treating patients with post-stroke depression[J]. Journal of Clinical Medicine in Practice, 2020, 24(17): 58-61. DOI: 10.7619/jcmp.202017015
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柴胡龙骨牡蛎汤联合抗抑郁药治疗脑卒中后抑郁的效果观察

  • 陕西省西安中医脑病医院 脑病一科, 陕西 西安, 710032

基金项目: 

陕西省西安市科技计划项目［201805103YX11SF37(13)］

详细信息
    通讯作者:

    余春,E-mail:346451287@qq.com

  • 中图分类号: R749.1

Effect of Chaihu Longgu Muli Decoction combined with anti-depressant in treating patients with post-stroke depression

  • First Department of Encephalopathy, Xi'an Traditional Chinese Medicine Brain Disease Hospital, Xi'an, Shaanxi, 710032

摘要

    摘要
  • 摘要: 目的 观察柴胡龙骨牡蛎汤联合抗抑郁药应用于脑卒中后抑郁患者中的临床效果。 方法 选择70例脑卒中后抑郁患者作为研究对象,采用随机数字表法分为对照组与研究组,每组35例。2组均接受常规治疗,对照组口服盐酸氟西汀胶囊治疗,研究组则在对照组基础上加用柴胡龙骨牡蛎汤治疗。比较2组临床疗效、不良反应情况和治疗前后汉密顿抑郁量表(HAMD)评分、美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力(ADL)评分、炎症因子［肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)］水平。 结果 研究组的治疗总有效率为94.3%, 高于对照组的74.3%, 差异有统计学意义(P<0.05); 治疗后,研究组HAMD、NIHSS评分低于对照组, ADL评分高于对照组,差异有统计学意义(P<0.01); 治疗后,研究组TNF-α、IL-1与IL-6水平均低于对照组,差异有统计学意义(P<0.01); 治疗期间,研究组药物不良反应发生率为8.6%, 对照组为5.7%, 差异无统计学意义(P>0.05)。 结论 柴胡龙骨牡蛎汤联合抗抑郁药应用于脑卒中后抑郁患者中安全有效,可改善抑郁状态,提高日常生活能力,降低炎症因子水平。
    Abstract: Objective To observe effect of Chaihu Longgu Muli Decoction combined with anti-depressant for post-stroke depression patients. Methods A total of 70 patients with post-stroke depression were selected as the study objects, and were randomly divided into control group and study group by random number table method. Both groups were given routine treatment, the control group(n=35)was treated with fluoxetine hydrochloride capsule, and the study group(n=35)was treated with Chaihu Longgu Muli Decoction based on the control group. Clinical curative effect, adverse reactions, Hamilton Depression Scale(HAMD)score before and after treatment, National Institutes of Health Stroke Scale(NIHSS)score, Ability of Daily Life(ADL)score, inflammatory factors ［tumor necrosis factor-α(TNF-α), interleukin-1(IL-1), interleukin-6(IL-6)］ levels were compared in two groups. Results The total effective rate of the study group was 94.3%, which was higher than 74.3% of the control group(P<0.05). After treatment, the scores of HAMD and NIHSS in the study group were lower than those in the control group, ADL score was higher than that of the control group(P<0.01). After treatment, levels of TNF-α, IL-1 and IL-6 in the study group were significantly lower than those in the control group(P<0.01). The incidence of adverse drug reactions was 8.6% in the study group and 5.7% in the control group, but no significant difference was found(P>0.05). Conclusion The combination of Chaihu Longgu Muli Decoction and anti-depressant has a significant effect for the patients with post-stroke depression, which can improve status of depression, - enhance daily life, and reduce inflammatory factors.
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出版历程
  • 收稿日期:  2020-07-03
  • 网络出版日期:  2020-09-29

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