Abstract: Objective To observe the clinical effect of epalrestat tablets combined with mecobalamin tablets in the treatment of diabetic peripheral neuropathy. Methods A total of 70 patients with diabetic peripheral neuropathy were randomly divided into two groups. Mecobalamin group(n=35)was given mecobalamin tablets, while combined group(n=35)was treated with epalrestat tablets and mecobalamin tablets in combination, and both groups were treated for 12 weeks. Michigan Neuropathy Screening Instrument(MNSI)was used to observe the changes of neurological symptoms and signs before and after treatment. Results Compared with treatment before, the scores of symptoms and signs of nervous system after treatment in the two groups were significantly improved(P<0.05). Compared with mecobalamin group, the combined group improved more significantly(P<0.05). Conclusion Epalrestat combined with mecobalamin is effective in the treatment of diabetic peripheral neuropathy.