Abstract: Objective To observe the significance of hypersensitivity C-reactive protein(hs-CRP)in predicting the prognosis of coronary heart disease patients with interventional therapy. Methods A total of 240 coronary heart disease patients in our hospital were selected as observation group(given percutaneous coronary intervention), and 260 coronary angiography patients were selected as control group during the same period. The serum of all recruiters were collected for detection of levels of hs-CRP. Patients in the observation group had regular visits in the hospital, and its incidence of adverse events was recorded. Results Compared with the control group, the level of hs-CRP in the observation group was significantly higher(P<0.05). Compared with preoperation, hs-CRP level after intervention was significantly higher(P<0.05). The incidence of adverse cardiovascular events in hs-CRP ≥3 ng/L group was significantly higher than hs-CRP <3 mg/L(13.66% versus 2.53%, P<0.05). Conclusion Patients with coronary heart disease have obvious local inflammatory response after interventional therapy. Detection of serum hs-CRP level has a certain effect in prediction of prognosis.