Abstract: Objective To investigate the effect of furosemide combined with levosimendan on cardiac function and N-terminal B-type natriuretic peptide(NT-proBNP)in patients with refractory heart failure. Methods A total of 80 patients with refractory heart failure were randomly divided into experimental group and control group, with 40 cases in each group. The control group was treated with furosemide, while the experimental group was treated with levosimendan combined with furosemide. Cardiac function index, inflammatory factor and clinical efficacy were compared between the two groups. Results After treatment, NT-proBNP, serum hypersensitive C-reactive protein(hS-CRP)and the levels of interleukin-6(IL-6)in the experimental group were significantly lower than those in the control group(P<0.05); left ventricular ejection fraction(LVEF)and stroke volume(SV)were significantly higher than those in the control group(P<0.05). The total effective rate of the experimental group was 80.00%, which was significantly higher than 57.50% of the control group(P<0.05). Conclusion The treatment of refractory heart failure with furosemide combined with levosimendan can significantly improve the heart function, and reduce the inflammatory response in patients with refractory heart failure.