心力衰竭合并心房颤动患者凝血指标、生化指标与静脉血栓发生情况分析

Analysis on coagulation indexes, biochemical indexes and occurrence of venous thrombosis in patients with heart failure and atrial fibrillation

  • 摘要: 目的 分析心力衰竭(简称心衰)合并心房颤动(简称房颤)患者凝血指标、生化指标水平与静脉血栓发生情况。 方法 选取86例慢性心衰患者作为研究对象,按是否合并房颤分为对照组(心衰组)和研究组(心衰合并房颤组),比较2组患者心功能分级情况和凝血指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、D-二聚体]、生化指标[血细胞比容(Hct)、C反应蛋白(CRP)、脑钠肽(BNP)]水平,并比较2组静脉血栓发生率。 结果 2组心功能Ⅱ级者比率比较,差异无统计学意义(P>0.05); 研究组心功能Ⅲ级者比率低于对照组,心功能Ⅳ级者比率高于对照组,差异有统计学意义(P<0.05); 研究组患者PT、APTT、D-二聚体水平高于对照组,差异有统计学意义(P<0.05); 研究组Hct、CRP、BNP水平高于对照组,差异有统计学意义(P<0.05); 研究组静脉血栓发生率为34.88%, 高于对照组的16.28%, 差异有统计学意义(P<0.05)。 结论 相较于心衰患者,心衰合并房颤患者的凝血指标、生化指标水平更高,静脉血栓发生率更高,临床治疗时应予以充分重视。

     

    Abstract: Objective To analyze the coagulation indexes, biochemical indexes and occurrence of venous thrombosis in patients with heart failure and atrial fibrillation. Methods A total of 86 patients with chronic heart failure were selected and divided into control group(heart failure group)and study group(heart failure combined with atrial fibrillation group)according to whether they were complicated with atrial fibrillation. Cardiac function grading and coagulation indicators such as prothrombin time(PT), activated partial thromboplastin time(APTT), D-dimer were compared between the two groups, and biochemical indicators such as hematocrit(Hct)and C-reactive protein(CRP), and brain natriuretic peptide(BNP)were compared. Besides, the incidence of venous thrombosis in both groups was compared. Results There was no significant difference in ratio of patients with grade Ⅱ of heart function between the two groups(P>0.05); the study group had lower ratio of patients with heart function grade Ⅲ than the control group, and higher ratio of patients with heart function grade Ⅳ than the control group(P<0.05); The levels of PT, APTT and D-dimer in the study group were higher than those in the control group, and the differences were statistically significant(P<0.05). The Hct, CRP and BNP levels of the study group were significantly higher than those of the control group(P<0.05). The incidence of venous thrombosis in the study group was 34.88%, which was significantly higher than 16.28% in the control group(P<0.05). Conclusion The incidence - of venous thrombosis, levels of coagulation indicators and biochemical indicators are higher in patientswith heart failure and atrial fibrillation compared to those with heart failure. Therefore, sufficient attention should be paid during clinical treatment.

     

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