Abstract: Objective To explore effect of oxytocin combined with carboprost methylate suppositories in prevention of hemorrhage induced by uterine inertia in cesarean section and its impact on blood pressure. Methods A total of 88 parturients with cesarean section were randomly divided into observation group and control group, with 44 cases in each group. The control group was treated with intravenous infusion of oxytocin, while the observation group was treated with oxytocin combined with carboprost methylate suppositories. The rate of postpartum hemorrhage, blood loss, blood pressure and adverse reactions were compared between the two groups. Results The rate of postpartum hemorrhage in the observation group was 4.55%, which was significantly lower than 18.18% in the control group(P<0.05). The blood loss in the observation group at 2, 24 h after surgery were significantly less than those in the control group(P<0.05). There was no statistically significant difference in the incidence of postoperative adverse reactions between the two groups(P>0.05). Conclusion Oxytocin combined with carboprost methylate suppositories has significant preventive effect on hemorrhage induced by uterine inertia in cesarean section, which can decrease the amount of bleeding, reduce the rate of bleeding, and maintain stable blood pressure.