Effect of Senna Granules in bowel preparation before examination of colonoscopy
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摘要: 目的 观察番泻叶颗粒联合复方聚乙二醇电解质散溶液(PEG-ELS)在结肠镜检查中的效果。 方法 将接受结肠镜检查的174例患者随机分为3组,即PEG-ELS 2 L组, PEG-ELS 3 L组, 联合用药组,每组58例。比较3组肠道准备质量、进镜时间、腺瘤检出率以及不良反应。 结果 联合用药组和PEG-ELS 3 L组肠道清洁度评分高于PEG-ELS 2 L组,差异均有统计学意义(P<0.05或P<0.01)。PEG-ELS 2 L组肠道准备合格率为70.70%, 低于PEG-ELS 3 L组的91.40%和联合用药组的93.10%, 差异有统计学意义(P<0.05或P<0.01)。联合用药组平均进镜时间为(4.80±0.31)min, 短于PEG-ELS 2 L组的(5.58±0.34)min和PEG-ELS 3 L组的(5.49±0.41)min, 但差异均无统计学意义(P>0.05)。3组左半结肠、右半结肠、横结肠气泡评分及气泡总评分比较,差异无统计学意义(P>0.05)。联合用药组腺瘤性息肉检出率高于其他2组,但差异无统计学意义(P>0.05)。联合用药组不良反应发生率低于PEG-ELS 3 L组,差异有统计学意义(P<0.05)。 结论 番泻叶颗粒联合PEG-ELS可以提高肠道准备质量、腺瘤检出率,且不会延长进镜时间和增加不良反应。
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关键词:
- 番泻叶颗粒 /
- 复方聚乙二醇电解质散 /
- 肠道准备质量 /
- 波士顿肠道准备评分量表 /
- 结肠镜检查
Abstract: Objective To observe the effect of Senna Granules combined with polyethylene glycol electrolyte solutions(PEG-ELS)in bowel preparation for colonoscopy. Methods A total of 174 patients with colonoscopy were randomly divided into three groups with 58 cases in each group, including PEG-ELS 2 L group, PEG-ELS 3 L group and combination group. The quality of bowel preparation, endoscopic time, adenoma detection rate and adverse reactions were compared among the three groups. Results The intestinal cleanliness scores of the combination group and the PEG-ELS 3 L group were significantly higher than those of the PEG-ELS 2 L group(P<0.05 or P<0.01). The qualified rate of intestinal preparation in the PEG-ELS 2 L group was 70.70%, which was significantly lower than 91.40% of the PEG-ELS 3 L group and 93.10% of the combination group(P<0.05 or P<0.01). The average time into terminal ileum in the combination group was(4.80±0.31)min, which was shorter than(5.58±0.34)min in the PEG-ELS 2 L group and(5.49±0.41)min in PEG-ELS 3 L group, but there were no significant differences(P>0.05). There were no significant differences in bubble scores of left colon, right colon and transverse colon and total bubble score among the three groups(P>0.05). The detection rate of adenomatous polyps in the combination group was significantly higher than that in the other two groups, but there was no significant difference(P>0.05). The incidence of adverse reactions in the combination group was significantly lower than that in the PEG-ELS 3 L group(P<0.05). Conclusion Senna Granules combined with PEG-ELS can improve the quality of bowel preparation and the detection rate of adenomatous polyps, and will not prolong the time into terminal ileum and increase occurrence of adverse reactions. -
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