Effect of nalmefene combined with naloxone in the treatment of patients with acute severe alcoholism
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摘要: 目的 观察纳美芬联合纳洛酮治疗急性重度酒精中毒的临床疗效。 方法 选取急性重度酒精中毒患者95例,随机分为对照组47例(给予纳洛酮治疗)和观察组48例(给予纳美芬联合纳洛酮治疗)。比较2组患者治疗前的改良早期预警评分(MEWS)、格拉斯哥昏迷评分(GCS)、饮酒量以及术中补液量。比较2组不同时间段的清醒率,清醒时间、非意识障碍症状消失时间、出院时间以及不良反应发生率。 结果 2组饮酒量、MEWS与GCS评分以及术中补液量比较,差异均无统计学意义(P>0.05)。观察组总有效率为93.75%, 高于对照组的78.72%, 差异有统计学意义(P<0.05)。观察组清醒时间、非意识障碍症状消失时间、出院时间均短于对照组,差异有统计学意义(P<0.05)。观察组1、2、3 h清醒率均高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为43.75%, 低于对照组的65.96%, 差异有统计学意义(P<0.05)。 结论 纳美芬联合纳洛酮治疗急性重度酒精中毒患者的疗效显著,可缩短治疗时间,促进患者清醒,且安全性较高。Abstract: Objective To observe the clinical efficacy of nalmefene combined with naloxone in the treatment of patients with acute severe alcoholism. Methods Totally 95 patients with acute severe alcoholism were randomly divided into control group(n=47, treated with naloxone)and observation group(n=48, treated with nalmefene and naloxone). Modified Early Warning Score(MEWS), Glasgow Coma Scale(GCS), alcohol consumption and intraoperative fluid infusion volume were compared between the two groups. Consciousness awakening rate at different time periods, time to consciousness awakening, disappearance time of unconsciousness symptoms, discharge time and incidence of adverse reactions were compared between the two groups. Results There were no significant differences in the amount of alcohol consumption, MEWS and GCS scores and intraoperative fluid infusion volume between the two groups(P>0.05). The total effective rate of the observation group was 93.75%, which was significantly higher than 78.72% of the control group(P<0.05). The time to consciousness awakening, the disappearance time of unconsciousness symptoms and the discharge time in the observation group were significantly shorter than those in the control group(P<0.05). The consciousness awakening rates at 1 hour, 2 and 3 hours in the observation group were significantly higher than those in the control group(P<0.05). The incidence of adverse reactions in the observation group was 43.75%, which was significantly lower than 65.96% in the control group(P<0.05). Conclusion Nalmefene combined with naloxone is effective and safe in the treatment of patients with acute severe alcoholism, which can shorten the therapeutic duration and promote awakening of consciousness.
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Keywords:
- nalmefene /
- naloxone /
- acute severe alcoholism /
- Modified Early Warning Score /
- Glasgow Coma Scale
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