Abstract: Objective To observe effect of domperidone combined with Kangfuxin Fluid in treating reflux esophagitis and its effect on levels of C-reactive protein(CRP), interleukin-6(IL-6), and interleukin-10(IL-10). Methods A total of 86 patients with reflux esophagitis were divided into experimental group and control group according to random number table method, with 43 cases in each group. The control group was treated with Kangfuxin Fluid alone, while the experimental group was treated with domperidone combined with Kangfuxin Fluid. The clinical efficacy, changes of serum CRP, IL-6 and IL-10 and adverse reactions occurred during treatment were compared between the two groups. Results The CRP, IL-6 and IL-10 levels after 8 weeks of treatment in both groups were significantly lower than those before treatment, and were significantly lower in the experimental group than those of the control group(P<0.05). The total effective rate of the experimental group was significantly higher than that of the control group(P<0.05). During treatment, there were no significant differences in the incidence rates of diarrhea, fatigue, constipation and other adverse reactions(P>0.05). Conclusion Dopperidone combined with Kangfuxin Fluid can effectively relieve the clinical symptoms of reflux esophagitis, reduce the levels of serum CRP, IL-6 and IL-10, and alleviate the inflammatory reactions.