Abstract: Objective To explore the effect of butylphthalide soft capsule on cerebral blood perfusion and cognitive function in patients with mild cognitive impairment after cerebral infarction. Methods A total of 90 patients with mild cognitive dysfunction after cerebral infarction were selected and randomly divided into control group and observation group, with 45 cases in each group. The control group was treated with conventional therapies such as anti-platelet aggregation and microcirculation improvement therapies, while the observation group was treated with butylphthalide soft capsules on the basis of the control group. The treatments of two groups were lasted for 2 weeks. Before and after treatment, the levels of cerebral blood perfusion indexes［cerebral blood flow(CBF), cerebral blood volume(CBV)and mean transit time(MTT)］, serological indexes［neuron specific enolase(NSE), homocysteine(Hcy)and cerebral active peptide 100-β(S-100 β)］and cognitive functions ［Montreal Cognitive Assessment Scale(MoCA)and Mini Mental State Examination(MMSE)］were compared between the two groups. Results After treatment, the CBF and CBV levels in both groups were significantly higher than those before treatment, while MTT was significantly shorter than that before treatment, and the CBF and CBV levels of the observation group were significantly higher - than those of the control group, and the MTT was significantly shorter than that of the control group (P<0.05). After treatment, the levels of NSE, Hcy and S-100 β in both groups were significantly lower than those before treatment, and the levels of NSE, Hcy and S-100 β in the observation group were significantly lower than those in the control group(P<0.05). After treatment, the MoCA score and the MMSE score in both groups were significantly higher than those before treatment, and the scores of the MoCA and the MMSE in the observation group were significantly higher than those in the control group(P<0.05). Conclusion Butylphthalide soft capsule can improve the cerebral blood perfusion of patients with mild cognitive impairment after cerebral infarction, reduce the levels of serum NSE, Hcy and S-100 β, and promote the recovery of cognitive function.