Abstract: Objective To investigate the value of creatine kinase(CK)in evaluating the clinical outcomes of patients with diabetic ketoacidosis. Methods Totally 40 diabetic patients were divided into study group with elevated CK level and control group with normal CK level, with 20 cases in each group. Fasting blood glucose(FBG), glycosylated hemoglobin(HbA1c), blood potassium, blood sodium, blood urea nitrogen(BUN), pH value, hemoglobin(Hb), bicarbonate(HCO₃^-)and C peptide levels were detected and compared between the two groups. The condition of comorbidities was recorded in both groups. Results The levels of HbA1c, FBG and BUN in the study group were significantly higher than those in the control group, while the levels of pH value, Hb and HCO₃^- were significantly lower than those in the control group(P<0.05). On admission, the level of C peptide in the study group was significantly lower than that in the control group(P<0.05). At 3 months after discharge, the level of C peptide in the study group was significantly higher than that on admission(P<0.05). The ratios of patients with diabetic peripheral neuropathy, diabetic nephropathy and diabetic retinopathy in the study group were significantly higher than those in the control group(P<0.05). Pearson correlation analysis showed that the level of CK was positively correlated with HbA1c level(r=0.336, P=0.012). Conclusion The levels of blood glucose in patients with diabetic ketoacidosis and elevated CK are significantly higher than those in patients with normal CK levels, while the incidence rates of diabetic peripheral neuropathy, diabetic nephropathy and diabetic retinopathy are - higher than those in patients with normal CK. CK level shows a certain value in evaluating the clinical outcomes of patients with diabetic ketoacidosis.