Detection of serum biomarkers related to type 2 diabetes mellitus and their analysis
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摘要: 目的 探讨2型糖尿病视网膜病变及肾脏病变患者的血清血管内皮生长因子(VEGF)、同型半胱氨酸(Hcy)、超敏C-反应蛋白(hs-CRP)水平变化及临床意义。 方法 将86例2型糖尿病患者纳入研究,其中2型糖尿病患者28例(A组),糖尿病肾病患者19例(B组),糖尿病视网膜病变患者24例(C组),糖尿病视网膜病变合并肾病患者15例(D组),同时选取同期健康体检者40例为对照组。观察并比较各组Hcy、VEGF、hs-CRP水平变化情况。 结果 A、B、C、D组血清VEGF、Hcy、hs-CRP水平高于对照组,且D组高于A、B、C组,差异有统计学意义(P<0.05)。C组中增殖期视网膜病变10例,非增殖期视网膜病变14例,且增殖期患者VEGF、Hcy、hs-CRP水平高于非增殖期患者,差异有统计学意义(P<0.05)。 结论 血清VEGF、Hcy、hs-CRP水平在2型糖尿病视网膜病变及肾脏病变患者和增殖期糖尿病视网膜病变患者中显著升高,说明其与疾病发展密切相关,可将其作为疾病诊断和判断视网膜病变程度的生物标志物。Abstract: Objective To explore the changes of serum vascular endothelial growth factor(VEGF), homocysteine(Hcy)as well as hypersensitivity C-reactive protein(hs-CRP)levels on retinopathy and kidney disease in patients with type 2 diabetes mellitus and their clinical significance. Methods A total of 86 patients with type 2 diabetes mellitus were selected in the study, including 28 patients with type 2 diabetes mellitus(group A), 19 patients with diabetic nephropathy(group B), and 24 patients with diabetic retinopathy( group C), 15 cases with diabetic retinopathy and kidney disease(group D), and 40 cases of healthy physical examination during the same period were selected as control group. The changes of Hcy, VEGF and hs-CRP levels in different groups were observed and compared. Results The levels of serum VEGF, Hcy as well as hs-CRP in groups A, B, C and D were significantly higher than those in the control group, and were significantly higher in the group D than those in groups A, B and C(P<0.05). There were 10 cases with proliferative retinopathy and 14 cases with non-proliferative retinopathy in group C, the levels of VEGF, Hcy and hs-CRP in the proliferative patients were significantly higher than those in the non-proliferative patients(P<0.05). Conclusion The levels of serum Hcy, VEGF and hs-CRP are significantly increased in diabetic retinopathy and kidney disease patients with type 2 diabetes mellitus and those with proliferative diabetic retinopathy, indicating that it is closely related to the development of the disease, and can be used as a biomarker for disease diagnosis and in judging the degree of retinopathy.
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