Abstract: Objective To investigate the efficacy of propofol in inhibiting dexamethasone sodium phosphate induced perineal pruritus in women. Methods A total of sixty patients undergoing elective gynecological surgery were randomly divided into experimental group and control group, with 30 cases in each group. Before anesthesia induction, the experimental group was given propofol injection intravenously, while the control group was given saline intravenously. Subsequently, both groups received intravenous injection of dexamethasone sodium phosphate. The perineal pruritus, the onset and duration of pruritus, visual analogue scale(VAS), sleep disturbance sedation score(Ramsay score)and adverse reactions were compared between the two groups. Results The total incidence of pruritus and severe pruritus in the experimental group were significantly lower than those in the control group(P< 0.05). Ramsay score in the experimental group was significantly higher than that in the control group(P< 0.05). Conclusion Propofol can effectively inhibit the perineal pruritus caused by dexamethasone sodium phosphate injection.