Abstract: Application of muscle chain theory in the rehabilitation treatment of stroke patients has been widely concerned, and it has significant effects in improving the core control ability, upper limb and lower limb function, posture control ability, pain, motor ability and so on. This research summarizes the relevant literaturesss at home and abroad, introduced the influence of muscle chain theory on the core control, posture control, motor ability and pain in stroke patients, connected the functions of joint chain, muscle chain and nerve chain, and provided new ideas for rehabilitation treatment of stroke patients.