Abstract: Objective To compare the effects of different skin flaps in repairing head and face skin defects. Methods A total of 60 patients with facial skin defects were selected, and all underwent flap repairing. They were divided into three groups according to different operation programs. Group A(n=14)conducted double side advancing flap repair, group B(n=21)used A-T flap repair, and group C(n=25)used rhomboid skin flap to repair defects. Defect areas and complication rates were compared, and scar conditions of three groups were compared after 1 year follow up. Results The defect sites of the three groups showed significant differences(P<0.05). All flaps survived, and there was no necrosis of flaps. The complication rates of group A, group B and group C were 7.14%, 9.52% and 8.00%, respectively, but there were no significant differences among the three groups(P>0.05). There were no significant differences in scar color, elasticity degree score and scar width among the three groups(P>0.05). The flatness score of group C was significantly lower than that of group A and group B(P<0.05). Conclusion Bilateral advancing skin flap, A-T skin flap and rhomboid skin flap repair can effectively repair skin defects of head and face, and rhomboid skin flap has smoother scar.