Comparison in efficacy of photodynamic therapy with 5-amino-ketovalic acid at different concentrations in treating patients with moderate to severe acne
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摘要: 目的 比较不同浓度5-氨基酮戊酸光动力疗法对中重度痤疮患者皮肤生理指标和疗效的影响。 方法 将88例中重度痤疮患者分为对照组(n=44)和观察组(n=44)。对照组采用浓度为5.0% 的5-氨基酮戊酸光动力进行治疗,观察组给予浓度为10.0%的5-氨基酮戊酸光动力治疗。比较2组临床疗效、皮肤生理指标、痤疮评分系统(GAGS)评分。 结果 观察组治疗有效率高于对照组,差异有统计学意义(P<0.05)。2组治疗后皮肤含水量增加,油脂和pH值均较治疗前降低,差异有统计学意义(P<0.05); 2组治疗后含水量、pH值差异无统计学意义(P>0.05); 观察组治疗后皮肤油脂少于对照组,差异有统计学意义(P<0.05); 2组治疗第1周、第3周GAGS评分逐渐降低,且观察组上述时点GAGS评分均低于对照组,差异有统计学意义(P<0.05)。 结论 10.0%浓度的5-氨基酮戊酸光动力治疗中重度痤疮的临床疗效显著且安全性高,可明显改善患者皮肤油脂分泌。Abstract: Objective To compare the effects of photodynamic therapy with 5- amino-ketovalic acid at different concentrations on skin physiological indexes and efficacy in treating moderate to severe acne. Methods A total of 88 patients with moderate and severe acne were divided into control group(n=44)and observation group(n=44). The control group was treated with photodynamic treatment of 5-amino-ketovalic acid at a concentration of 5.0%, while the observation group was treated with photodynamic treatment of 5-amino-ketovalic acid at a concentration of 10.0%. The clinical efficacy, skin physiological indexes and Acne Scoring System(GAGS)scores of the two groups were compared. Results The effective rate in the observation group was significantly higher than that in the control group(P<0.05); after treatment, the water content of the two groups increased, and the oil content and pH value decreased compared with the treatment before(P<0.05), there were no significant differences in the water content and pH value between the two groups(P>0.05). The oil content of skin in the observation group was lower than that of the control group(P<0.05). The GAGS scores of the two groups decreased gradually at the first and third weeks of treatment(P<0.05), and the GAGS scores of the observation group were lower than those of the control group at the above time points(P<0.05). Conclusion Photodynamic therapy with 5-amino-ketovalic acid at a concentration of 10.0% has significant clinical efficacy and higher safety in the treatment of moderate to severe acne, and can obviously improve sebum secretion of patients.
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Keywords:
- acne /
- skin oil /
- water content /
- 5-amino-ketovalic acid /
- Acne Scoring System
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