Abstract: Objective To investigate the effect of laparoscopic enucleation of uterine adenomyoma combined with gonadotropin releasing hormone agonist(GnRH-a)in the treatment of patients with uterine adenomyoma. Methods Totally 270 patients with uterine adenomyoma were divided into control group(n=150, treated with total laparoscopic hysterectomy)and observation group(n=120, treated with laparoscopic enucleation of uterine adenomyoma and GnRH-a). The operation-related indexes, clinical indexes and recurrence condition were compared between the two groups. Results There were no significant differences in operation time, intraoperative blood loss and hospital stay between the two groups(P>0.05). In the observation group, carbohydrate antigen 125, score of menstrual volume and score of dysmenorrhea were significantly lower than those before operation, while hemoglobin level was significantly higher than that before operation(P<0.05). There were significant differences in carbohydrate antigen 125 and hemoglobin levels in the control group before and after operation(P<0.05). In the observation group, 6 cases with recurrence of uterine adenomyoma were found by transvaginal ultrasonography after operation, and 4 cases in the control group still had periodic lower abdominal pain after operation. Conclusion Laparoscopic enucleation of uterine adenomyoma combined with GnRH-a can relieve dysmenorrhea and reduce menstrual volume.