Abstract: Objective To explore the value of neutrophil to lymphocyte ratio(NLR), platelet to lymphocyte ratio(PLR)and echocardiography related parameters in evaluating the short-term prognosis of patients with acute ST segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI). Methods Totally 200 STEMI patients with PCI were selected. According to the occurrence of major adverse cardiovascular events(MACE), the patients were divided into non-MACE group(n=143)and MACE group(n=57). The levels of NLR and PLR were compared between the two groups at 1 day, 3 and 5 days after operation. Echocardiographic parameters［left ventricular wall thickness(LVPW), left atrial volume(LAV), cardiac output(CO), left ventricular ejection fraction(LVEF), maximum flow velocity of mitral orifice in early diastolic phase(E), deceleration time of E peak blood flow(DT)and wall motion score index(WMSI)］were compared between the two groups at 3 days after operation. COX regression model was used to analyze the related factors of recurrence of MACE in STEMI patients after PCI. Results The levels of NLR and PLR in the MACE group were significantly higher than those in the non-MACE group at 1 day, 3 and 5 days after operation(P<0.05). At 3 days after operation, the LVPW, E and WMSI of the MACE group were significantly higher than those of the non-MACE group, while the LAV, CO, LVEF and DT were significantly lower than those of the non-MACE group(P<0.05). Multivariate COX regression analysis showed that NLR, PLR and echocardiographic parameters were correlated with risk of MACE in STEMI patients after PCI(P<0.05). Conclusion NLR, PLR and echocardiographic parameters - are correlated with the increased risk of MACE in STEMI patients after PCI, which can better predict the occurrence of MACE and have a positive significance for improving the short-term prognosis of STEMI patients.