老年原发性高血压患者生理指标及氧化应激指标的变化和意义

刘欢, 刘永霞, 刘燕, 赵妮

刘欢, 刘永霞, 刘燕, 赵妮. 老年原发性高血压患者生理指标及氧化应激指标的变化和意义[J]. 实用临床医药杂志, 2020, 24(23): 88-91. DOI: 10.7619/jcmp.202023027
引用本文: 刘欢, 刘永霞, 刘燕, 赵妮. 老年原发性高血压患者生理指标及氧化应激指标的变化和意义[J]. 实用临床医药杂志, 2020, 24(23): 88-91. DOI: 10.7619/jcmp.202023027
LIU Huan, LIU Yongxia, LIU Yan, ZHAO Ni. Changes of physiological indexes and oxidative stress indexes in elderly patients with essential hypertension and their significance[J]. Journal of Clinical Medicine in Practice, 2020, 24(23): 88-91. DOI: 10.7619/jcmp.202023027
Citation: LIU Huan, LIU Yongxia, LIU Yan, ZHAO Ni. Changes of physiological indexes and oxidative stress indexes in elderly patients with essential hypertension and their significance[J]. Journal of Clinical Medicine in Practice, 2020, 24(23): 88-91. DOI: 10.7619/jcmp.202023027

老年原发性高血压患者生理指标及氧化应激指标的变化和意义

详细信息
    通讯作者:

    刘永霞, E-mail: muchi2129@163.com。

  • 中图分类号: R544.1;R446.11

Changes of physiological indexes and oxidative stress indexes in elderly patients with essential hypertension and their significance

  • 摘要: 目的 探讨老年原发性高血压(EH)患者臂踝脉搏波传导速度(baPWV)、超敏C反应蛋白(hs-CRP)、脂蛋白相关磷脂酶A2(Lp-PLA2)及氧化应激指标的变化和意义。 方法 将170例老年EH患者分为硬化组80例和对照组90例。比较2组的baPWV、hs-CRP、Lp-PLA2、超氧化物歧化酶(SOD)、丙二醛(MDA)及血脂指标水平,并分析baPWV、hs-CRP、Lp-PLA2、SOD、MDA的相关性。 结果 硬化组血清甘油三酯(TG)、总胆固醇(TC)、低密度值蛋白胆固醇(LDL-C)、baPWV、hs-CRP、Lp-PLA2、MDA高于对照组,差异均有统计学意义(P<0.05)。硬化组血清SOD低于对照组,差异有统计学意义(P<0.05); 老年EH伴有颈动脉粥样硬化患者baPWV、hs-CRP、Lp-PLA2、MDA与颈动脉内膜中膜厚度(IMT)呈显著正相关, SOD与IMT呈显著负相关。 结论 老年EH伴有颈动脉粥样硬化的患者baPWV、hs-CRP、Lp-PLA2、MDA水平增高, SOD降低,或可促进颈动脉粥样硬化发展。
    Abstract: Objective To investigate the changes of brachial-ankle pulse wave velocity(baPWV), hypersensitive C-reactive protein(hs-CRP), lipoprotein-associated phospholipase A2(LP-PLA2)as well as oxidative stress indexes in elderly patients with essential hypertension(EH)and their significance. Methods A total of 170 elderly patients with EH were divided into sclerosis group(n=80)and control group(n=90). The levels of baPWV, hs-CRP, LP-PLA2, superoxide dismutase(SOD), malondialdehyde(MDA)and blood lipid in the two groups were compared, and the correlations among baPWV, hs-CRP, LP-PLA2, SOD and MDA were analyzed. Results Serum triglyceride(TG), total cholesterol(TC), low density lipoprotein-cholestero(LDL-C), baPWV, hs-CRP, LP-PLA2 and MDA in the sclerosis group were significantly higher than those in the control group(P<0.05). The serum SOD level of the sclerosis group was significantly lower than that of the control group(P< 0.05). In the elderly EH patients with carotid atherosclerosis, baPWV, hs-CRP, LP-PLA2 and MDA presented significant positive correlations with intima-media thickness(IMT), while SOD and IMT presented a significant negative correlation. Conclusion In the elderly EH patients with carotid atherosclerosis, the levels of baPWV, hs-CRP, LP-PLA2 and MDA are increased and SOD is decreased, which may promote the development of carotid atherosclerosis.
  • PERTICONE M, TRIPEPI G, MAIO R, et al. Risk reclassification ability of uric acid for cardiovascular outcomes in essential hypertension[J]. Int J Cardiol, 2017, 243: 473-478.

    SEVENCAN N O, OZKAN A E. Renal resistive index and aortic knob width relationship as a predictor of renal prognosis in essential hypertension[J]. Medicine(Madr), 2018, 97(40): e12434.

    刘凤敏, 张艳敏. 炎症与老年原发性高血压病的关联机制研究进展[J]. 中国全科医学, 2018, 21(29): 3644-3647.
    瘙塁EKER T, TÜRKOĜLU C, HARBALIOĜLU H, et al. Epicardial Fat Thickness is Associated with Abnormal Left Ventricle Geometry in Newly Diagnosed Hypertension. [J]. Acta Cardiol Sin, 2018, 34(3): 280-287.
    杨芳, 依不拉音·阿不都瓦衣提, 刘继文. 高血压合并糖尿病患者血管内皮因子受体与超氧化物歧化酶水平的观察[J]. 心脑血管病防治, 2018, 18(3): 202-204.

    KÜÇÜKDILER A H E, VARLI M, YAVUZ Ö, et al. Evaluation of oxidative stress parameters and antioxidant status in plasma and erythrocytes of elderly diabetic patients with sarcopenia[J]. J Nutr Heal Aging, 2019, 23(3): 239-245.

    老年高血压诊断与治疗中国专家共识组. 老年高血压诊断与治疗2008中国专家共识[J]. 中华内科杂志, 2008, 47(12): 1046-1050.
    周丹, 周磊, 胡晓燕. H型高血压患者认知功能障碍程度和炎症及氧化应激因子水平的相关性[J]. 中华高血压杂志, 2018, 26(9): 871-874.

    YU Y, GAO Q, XIA W, et al. Association between physical exercise and biomarkers of oxidative stress among middle-aged and elderly community residents with essential hypertension in China[J]. Biomed Res Int, 2018, 2018: 4135104.

    姜苏蓉, 卢妙, 王森, 等. 老年高血压患者心率变异性与动脉硬化的相关性研究[J]. 中国临床保健杂志, 2019, 22(5): 596-600.
    王杰, 裴育, 陈康, 等. 肱踝脉搏波速度和体重指数对糖尿病合并高血压发生风险的独立和联合作用[J]. 中华内分泌代谢杂志, 2018, 34(4): 287-294.
    陈斌, 许友榜, 刘育成. 高血压患者脂蛋白相关磷脂酶A2与肱踝动脉脉搏波传导速度及踝臂血压指数的相关性[J]. 中华高血压杂志, 2018, 26(7): 649-653.
    郭力鹏, 许青宗, 尚兰. 原发性高血压患者肱-踝脉搏波传导速度与心率变异性、心功能指标的相关性研究[J]. 中国医师进修杂志: 综合版, 2018(3): 227-230.
    曲春花, 柳晖, 唐剑英. 原发性高血压患者超敏C反应蛋白与动脉脉搏波速度的关系研究[J]. 中国临床保健杂志, 2020, 23(1): 80-84.
    陈林, 周菲, 李璐. 肱踝脉搏波速度测定在心血管病风险评估中的应用[J]. 心脏杂志, 2019, 31(2): 164-168.
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出版历程
  • 收稿日期:  2020-10-21
  • 网络出版日期:  2020-12-20

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