Abstract: Objective To explore the effect of anticoagulant therapy in improvement of hypocalcemia in patients with severe pancreatitis. Methods A total of 71 patients with severe pancreatitis were divided into anticoagulant group(n=34)and non-anticoagulant group(n=37). The non-anticoagulant group was given routine treatment, and the anticoagulant group was given low molecular weight heparin sodium injection on the basis of routine treatment. Venous blood calcium levels on the day of admission and on the 3rd and 7th day of treatment were compared between the two groups. Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)scores on the 3rd and 7th day of treatment were compared between the two groups, and the improvement of anticoagulant therapy to the overall condition was analyzed. Results After 3 days of treatment, there was no significant difference in serum calcium level between the two groups(P>0.05); the APACHE Ⅱ score of the anticoagulation group was significantly better than that of the non-anticoagulation group(P<0.05).After 7 days of treatment, the blood calcium level of the anticoagulant group was significantly higher than that of the non-anticoagulant group(P<0.05); there was no statistically significant difference in APACHE Ⅱ score between the two groups(P>0.05). Conclusion Anticoagulant therapy can effectively treat hypocalcemia in patients with severe pancreatitis, and can improve APACHE Ⅱ score in the early stage, but it may not have a significant effect on the prognosis of the disease.