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经皮肺穿刺活检联合肿瘤标志物检测在肺部占位性病变中的诊断价值

Value of percutaneous lung puncture and biopsy combined with detection of tumor markers in diagnosis of pulmonary occupying lesions

    摘要
  • 摘要: 目的 探讨CT引导下经皮肺穿刺活检联合肿瘤标志物检测在肺部占位性病变诊断中的应用价值。 方法 选取206例肺部占位性病变患者为研究对象,均接受CT引导下经皮肺穿刺活检及肿瘤标志物检测。以手术病理检查结果为金标准,分析CT引导下经皮肺穿刺活检联合肿瘤标志物检测在肺部占位性病变中的应用价值。将恶性病变患者纳入恶性组,将良性病变患者纳入良性组,比较2组肿瘤标志物水平。 结果 恶性组神经特异烯醇化酶(NSE)、癌胚抗原(CEA)水平高于良性组,差异有统计学意义(P<0.05); 受试者工作特征曲线(ROC)曲线显示, NSE、CEA检测用于诊断肺部良恶性病变的AUC分别为0.812、0.805; 以手术病理检查结果为金标准,NSE检测诊断肺部占位性病变灵敏度、特异度、准确度分别为69.54%、70.91%、69.90%; CEA检测诊断肺部占位性病变灵敏度、特异度、准确度分别为70.20%、67.27%、69.42%; CT引导下经皮肺穿刺活检诊断肺部占位性病变灵敏度、特异度、准确度92.05%、81.82%、89.32%; CT引导下经皮肺穿刺活检联合肿瘤标志物检测肺部占位性病变灵敏度为96.03%, 特异度为83.64%, 准确度为92.72%; ROC曲线显示, CT引导下经皮肺穿刺活检联合肿瘤标志物检测用于诊断肺部良恶性病变的AUC为0.911。 结论 CT引导下经皮肺穿刺活检联合肿瘤标志物检测在肺部占位性病变具有较高诊断价值,可提高恶性肺部疾病诊断准确性。

     

    Abstract: Objective To explore the application value of CT-guided percutaneous lung puncture and biopsy combined with tumor markers detection in diagnosis of pulmonary occupying lesions. Methods A total of 206 patients with pulmonary occupying lesions were selected as study objects, and all underwent CT-guided percutaneous lung puncture and biopsy combined with tumor markers detection. Taking surgical pathologic examination results as gold standard, the application value of CT-guided percutaneous lung puncture and biopsy combined with tumor markers detection in pulmonary occupying lesions was analyzed. Patients with malignant lesions were included in the malignant group and those with benign lesions were included in the benign group, and the levels of tumor markers in the two groups were compared. Results The levels of NSE and CEA in the malignant group were higher than those in the benign group, and the differences were statistically significant(P<0.05); the receiver operating characteristic curve(ROC)found that the AUCs of NSE and CEA for the diagnosis of benign and malignant lung lesions were 0.812 and 0.805, respectively; the sensitivity, specificity and accuracy of NSE detection in diagnosis of lung space-occupying lesions were 69.54%, 70.91% and 69.90%, respectively. The sensitivity, specificity and accuracy of CEA detection in diagnosis of lung space-occupying lesions were 70.20%, 67.27% and 69.42% respectively. The sensitivity, specificity and accuracy of CT-guided percutaneous lung biopsy in the diagnosis of lung space-occupying lesions were 92.05%, 81.82% and 89.32%. The sensitivity, specificity and accuracy of CT guided percutaneous lung biopsy combined with tumor markers detecting in the diagnosis - of lung space-occupying lesions were 96.03%, 83.64% and 92.72%. ROC found that the AUC of CT guided percutaneous lung biopsy combined with tumor markers detection in the diagnosis of benignand malignant pulmonary lesions was 0.911. Conclusion CT-guided percutaneous lung puncture and biopsy combined with tumor markers detection has higher diagnostic value in pulmonary occupying lesions and can improve the diagnostic accuracy of malignant lung diseases

     

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