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经皮肺穿刺活检联合肿瘤标志物检测在肺部占位性病变中的诊断价值

殷波, 赵寅滢, 秦楚

殷波, 赵寅滢, 秦楚. 经皮肺穿刺活检联合肿瘤标志物检测在肺部占位性病变中的诊断价值[J]. 实用临床医药杂志, 2020, 24(24): 6-9. DOI: 10.7619/jcmp.202024002
引用本文: 殷波, 赵寅滢, 秦楚. 经皮肺穿刺活检联合肿瘤标志物检测在肺部占位性病变中的诊断价值[J]. 实用临床医药杂志, 2020, 24(24): 6-9. DOI: 10.7619/jcmp.202024002
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YIN Bo, ZHAO Yinying, QING Chu. Value of percutaneous lung puncture and biopsy combined with detection of tumor markers in diagnosis of pulmonary occupying lesions[J]. Journal of Clinical Medicine in Practice, 2020, 24(24): 6-9. DOI: 10.7619/jcmp.202024002
Citation: YIN Bo, ZHAO Yinying, QING Chu. Value of percutaneous lung puncture and biopsy combined with detection of tumor markers in diagnosis of pulmonary occupying lesions[J]. Journal of Clinical Medicine in Practice, 2020, 24(24): 6-9. DOI: 10.7619/jcmp.202024002
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经皮肺穿刺活检联合肿瘤标志物检测在肺部占位性病变中的诊断价值

  • 南京医科大学附属无锡市人民医院 呼吸与危重症科, 江苏 无锡, 214021

详细信息

  • 中图分类号: R563;R443

Value of percutaneous lung puncture and biopsy combined with detection of tumor markers in diagnosis of pulmonary occupying lesions

  • Department of Respiration and Critical Care Unit, Wuxi City People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, 214021

摘要

    摘要
  • 摘要: 目的 探讨CT引导下经皮肺穿刺活检联合肿瘤标志物检测在肺部占位性病变诊断中的应用价值。 方法 选取206例肺部占位性病变患者为研究对象,均接受CT引导下经皮肺穿刺活检及肿瘤标志物检测。以手术病理检查结果为金标准,分析CT引导下经皮肺穿刺活检联合肿瘤标志物检测在肺部占位性病变中的应用价值。将恶性病变患者纳入恶性组,将良性病变患者纳入良性组,比较2组肿瘤标志物水平。 结果 恶性组神经特异烯醇化酶(NSE)、癌胚抗原(CEA)水平高于良性组,差异有统计学意义(P<0.05); 受试者工作特征曲线(ROC)曲线显示, NSE、CEA检测用于诊断肺部良恶性病变的AUC分别为0.812、0.805; 以手术病理检查结果为金标准,NSE检测诊断肺部占位性病变灵敏度、特异度、准确度分别为69.54%、70.91%、69.90%; CEA检测诊断肺部占位性病变灵敏度、特异度、准确度分别为70.20%、67.27%、69.42%; CT引导下经皮肺穿刺活检诊断肺部占位性病变灵敏度、特异度、准确度92.05%、81.82%、89.32%; CT引导下经皮肺穿刺活检联合肿瘤标志物检测肺部占位性病变灵敏度为96.03%, 特异度为83.64%, 准确度为92.72%; ROC曲线显示, CT引导下经皮肺穿刺活检联合肿瘤标志物检测用于诊断肺部良恶性病变的AUC为0.911。 结论 CT引导下经皮肺穿刺活检联合肿瘤标志物检测在肺部占位性病变具有较高诊断价值,可提高恶性肺部疾病诊断准确性。
    Abstract: Objective To explore the application value of CT-guided percutaneous lung puncture and biopsy combined with tumor markers detection in diagnosis of pulmonary occupying lesions. Methods A total of 206 patients with pulmonary occupying lesions were selected as study objects, and all underwent CT-guided percutaneous lung puncture and biopsy combined with tumor markers detection. Taking surgical pathologic examination results as gold standard, the application value of CT-guided percutaneous lung puncture and biopsy combined with tumor markers detection in pulmonary occupying lesions was analyzed. Patients with malignant lesions were included in the malignant group and those with benign lesions were included in the benign group, and the levels of tumor markers in the two groups were compared. Results The levels of NSE and CEA in the malignant group were higher than those in the benign group, and the differences were statistically significant(P<0.05); the receiver operating characteristic curve(ROC)found that the AUCs of NSE and CEA for the diagnosis of benign and malignant lung lesions were 0.812 and 0.805, respectively; the sensitivity, specificity and accuracy of NSE detection in diagnosis of lung space-occupying lesions were 69.54%, 70.91% and 69.90%, respectively. The sensitivity, specificity and accuracy of CEA detection in diagnosis of lung space-occupying lesions were 70.20%, 67.27% and 69.42% respectively. The sensitivity, specificity and accuracy of CT-guided percutaneous lung biopsy in the diagnosis of lung space-occupying lesions were 92.05%, 81.82% and 89.32%. The sensitivity, specificity and accuracy of CT guided percutaneous lung biopsy combined with tumor markers detecting in the diagnosis - of lung space-occupying lesions were 96.03%, 83.64% and 92.72%. ROC found that the AUC of CT guided percutaneous lung biopsy combined with tumor markers detection in the diagnosis of benignand malignant pulmonary lesions was 0.911. Conclusion CT-guided percutaneous lung puncture and biopsy combined with tumor markers detection has higher diagnostic value in pulmonary occupying lesions and can improve the diagnostic accuracy of malignant lung diseases
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  • 郑琦, 万书友, 郭华. CT全瘤灌注扫描在诊断肺部占位性病变良恶性的作用研究[J]. 医学影像学杂志, 2018, 28(12): 2048-2050

    , 2081.
    金艺凤, 产翠翠, 田静, 等. 超声与CT引导下经皮肺穿刺活检诊断周围型肺癌的临床应用价值[J]. 临床超声医学杂志, 2016, 18(6): 415-417.
    杨敏, 王娇, 熊伟, 等. PET/CT联合CEA、CA125、CY21-1、NSE对单发性肺部占位性病变鉴别诊断价值的研究[J]. 新疆医科大学学报, 2018, 41(9): 1087-1091.
    龙成娟, 史恒峰, 丁国正, 等. CT引导经皮肺穿刺活检术在肺部占位性病变诊断中的应用[J]. 实用临床医药杂志, 2020, 24(5): 28-31.
    胡煜, 信涛. CT引导下经皮肺穿刺活检术对肺部占位性病变的临床诊断意义和安全性分析[J]. 现代肿瘤医学, 2018, 26(19): 3070-3072.
    张在炬, 丁正强, 陈亚明. 18F-FDG PET-CT和肿瘤标志物诊断肺癌的效果比较[J]. 实用癌症杂志, 2020, 35(5): 786-789.
    李倩, 王江, 张惠中. 肿瘤标志物在肺癌检验中的临床应用[J]. 重庆医学, 2017, 46(46): 130-132.
    张萍, 王红义, 杨迎桂, 等. 血清CEA, ProGRP, NSE和CYFRA21-1联合诊断在肺癌诊断中的应用研究[J]. 现代检验医学杂志, 2016, 31(2): 56-59.
    杜淑英. 血清CEA CYFRA21-1 NSE ProGRP SCCAg水平检测诊断肺癌的价值分析[J]. 中国药物与临床, 2020, 20(11): 1899-1900.
    张丽英, 傅冠华, 吴俊琪. 4项血清肿瘤标志物在肺癌辅助诊断和疗效评估中的价值[J]. 检验医学, 2019, 34(4): 331-334.
    李华, 赵宝祥, 张亚君, 等. miRNA、CEA及NSE联合诊断对早期肺癌的诊断价值[J]. 中国实验诊断学, 2020, 24(6): 906-909.
    周和平, 王硕华, 杨鸿捷. 多普勒超声联合CT三维成像定位在周围型肺癌穿刺活检中的应用[J]. 中国CT和MRI杂志, 2019, 17(9): 55-57

    , 90.
    张妍蓓. 经皮肺穿刺活检术在肺占位性病变中的应用[J]. 重庆医学, 2018, 47(29): 3770-3772.
    李雪, 张申众, 袁秀敏, 等. CT引导下经皮肺穿刺活检诊断早期肺癌的意义及其与超声的比较分析[J]. 实用癌症杂志, 2019, 34(4): 603-606.
    王炯, 颜瑾, 徐轲, 等. 81例CT引导下经皮肺穿刺活检标本临床病理结果[J]. 临床与病理杂志, 2017, 37(4): 713-71
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出版历程
  • 收稿日期:  2020-11-02
  • 网络出版日期:  2020-12-29

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