Abstract: Objective To explore the effect of different anesthesia methods for patients with lung cancer and its influences on stress indexes, hemodynamics and immune function. Methods A total of 100 patients with lung cancer were divided into control group(n=50)and observation group(n=50)according to different anesthesia methods. The control group was given general anesthesia, and the observation group was given ultrasound-guided paravertebral block. The anesthesia effect, perioperative changes of hemodynamics, stress indexes and immune function were compared between the two groups. Results Visual Analogue Scale(VAS)scores at 4 and 12 h after operation in the observation group were significantly lower than those in the control group(P<0.05). There was no statistically significant difference in postoperative Ramsay scores between the two groups(P>0.05). At 4 h after operation, heart rate(HR), systolic blood pressure(SBP)and mean arterial pressure(MAP)in the observation group were significantly lower than those in the control group(P<0.05). The levels of cortisol, tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the observation group were significantly lower than those in the control group(P<0.05). The levels of CD3⁺, CD4⁺, CD8⁺ and CD4⁺/CD8⁺ in the observation group were significantly higher than those in the control group(P<0.05). Conclusion Ultrasound-guided paravertebral block can improve the stress indexes, and has little impacts on the hemodynamics and immune function for lung cancer surgery patients.