Effect of different anesthesia methods on hemodynamics and immune function for patients with lung cancer
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摘要: 目的 探讨不同麻醉方法对肺癌患者的效果以及对应激指标、血流动力学、免疫功能的影响。 方法 将100例肺癌患者根据不同麻醉方式分为对照组(n=50)和观察组(n=50)。对照组给予全身麻醉,观察组给予超声引导椎旁神经阻滞麻醉。比较2组麻醉效果和围术期血流动力学、应激指标、免疫功能的变化。 结果 术后4、12 h, 观察组视觉模拟评分法(VAS)评分低于对照组,差异有统计学意义(P<0.05)。2组术后Ramsay评分差异无统计学意义(P>0.05)。术后4 h, 观察组心率(HR)、收缩压(SBP)、平均动脉压(MAP)水平均低于对照组,差异有统计学意义(P<0.05); 观察组皮质醇、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平均低于对照组,差异有统计学意义(P<0.05); 观察组CD3+、CD4+、CD8+、CD4+/CD8+ 水平均高于对照组,差异有统计学意义(P<0.05)。 结论 超声引导椎旁神经阻滞麻醉可改善肺癌手术患者的应激指标,且对血流动力学、免疫功能影响小。Abstract: Objective To explore the effect of different anesthesia methods for patients with lung cancer and its influences on stress indexes, hemodynamics and immune function. Methods A total of 100 patients with lung cancer were divided into control group(n=50)and observation group(n=50)according to different anesthesia methods. The control group was given general anesthesia, and the observation group was given ultrasound-guided paravertebral block. The anesthesia effect, perioperative changes of hemodynamics, stress indexes and immune function were compared between the two groups. Results Visual Analogue Scale(VAS)scores at 4 and 12 h after operation in the observation group were significantly lower than those in the control group(P<0.05). There was no statistically significant difference in postoperative Ramsay scores between the two groups(P>0.05). At 4 h after operation, heart rate(HR), systolic blood pressure(SBP)and mean arterial pressure(MAP)in the observation group were significantly lower than those in the control group(P<0.05). The levels of cortisol, tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the observation group were significantly lower than those in the control group(P<0.05). The levels of CD3+, CD4+, CD8+ and CD4+/CD8+ in the observation group were significantly higher than those in the control group(P<0.05). Conclusion Ultrasound-guided paravertebral block can improve the stress indexes, and has little impacts on the hemodynamics and immune function for lung cancer surgery patients.
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Keywords:
- ultrasound /
- paravertebral block /
- lung cancer /
- stress indicators /
- hemodynamics
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