Abstract: Objective To observe the clinical efficacy of modified Shenling Baizhu Powder combined with apatinib in the treatment of advanced gastric cancer. Methods A total of 60 patients were randomly divided into two groups, with 30 cases in each group.The treatment group was treated with modified Shenling Baizhu Powder combined with apatinib, while the control group was only treated with apatinib.The treatment effect and the incidence of adverse reactions were compared between the two groups. Results The disease control rate and effective rate of traditional Chinese medicine syndrome of the treatment group were significantly higher, the incidence of adverse reaction above grading one was significantly lower than that of the control group(P<0.05). Conclusion The clinical effect of modified Shenling Baizhu Powder combined with apatinib in the treatment of advanced gastric cancer is better than that of apatinib alone, and combined treatment can reduce the adverse reactions of apatinib as well as improve the quality of life.