Abstract: Objective To investigate the effect of body temperature control on vital signs and inflammatory factors after laparoscopic subtotal gastrectomy. Methods Eighty-three patients with laparoscopic subtotal gastrectomy were selected and randomly divided into control group(n=41)and experimental group(n=42). The control group was given routine warm-keeping measures during anesthesia recovery and returning to the ward, while the experimental group was given measures for body temperature control during anesthesia recovery and returning to the ward. The rectal temperature during operation, blood pressure, heart rate and ear temperature at different time points after operation as well as levels of inflammatory factors were compared between the two groups. Results The rectal temperature of the experimental group was significantly higher than that of the control group at the time points of 1, 2, 3 h after anesthesia and the end of operation, the heart rates at 0.5, 1, 2 and 3 h after operation were significantly lower than those of the control group, the ear temperature was significantly higher than that of the control group, and the postoperative levels of inflammatory factors were significantly lower than those of the control group(P<0.05). Conclusion Body temperature control can enhance the stability of vital signs and reduce the levels of inflammatory factors in patients with laparoscopic subtotal gastrectomy.