Abstract: Objective To observe the clinical efficacy of low-temperature plasma technique under nasal endoscopy in treatment of children with obstructive sleep apnea-hypopnea syndrome(OSAHS). Methods A total of 61 OSAHS cases with surgical treatment were divided into observation and control groups according to different surgical methods. The observation group(n=36)received nasal endoscopic low-temperature plasma radiofrequency ablation, while the control group(n=25)received endoscopic adenoidectomy with electric cutter and tonsillectomy with high frequency electric cutter. Surgery time, intraoperative blood loss, pain degree, postoperative re-bleeding rate and the clinical efficacy of two groups were compared. Results The total effective rates were higher in both groups, but the differences were not statistically significant(P>0.05). Compared with the control group, the observation group had significantly shorter operation time, less intraoperative blood loss and postoperative pain, and lower postoperative re-bleeding rate(P<0.05 or P<0.01). Conclusion Nasal endoscopic low-temperature plasma technique is effective in treatment of OSAHS in children, and it has the advantages of short operation time, less intraoperative blood loss as well as postoperative pain, fewer complications, and quicker recovery.