Abstract: Objective To explore the effect of individualized nutrition and exercise therapy on pregnancy outcomes of patients with gestational diabetes mellitus(GDM). Methods Totally 120 pregnant women with GDM were divided into two groups, with 60 cases in each group. Observation group was treated with individualized nutrition and exercise therapy, while control group was treated with routine guidance. Fasting blood glucose(FPG), 2 h postprandial blood glucose(2 hPG), total cholesterol(TC)and triglyceride(TG)levels were compared between the two groups. The pregnancy outcomes of the two groups were compared. Results After treatment, the levels of FPG, 2 hPG, TC and TG decreased significantly in the observation group(P<0.01), and the levels of 2 hPG, TC and TG decreased significantly in the control group(P<0.05). The incidence rates of cesarean section, hydramnios, macrosomia, fetal growth restriction and neonatal respiratory distress syndrome in the observation group were significantly lower than those in the control group(P<0.05). Conclusion Individualized nutrition and exercise therapy can significantly improve the blood glucose status of pregnant women with GDM and reduce the incidence of adverse pregnancy outcomes.