Abstract: Objective To investigate the effect of methyldopa combined with nicardipine on the hemodynamics and micro-inflammatory state of patients with preeclampsia. Methods A total of 91 patients with preeclampsia were divided into observation group(n=31), control group one(n=30)and control group two(n=30)according to different treatment methods. The control group one was treated with nidipine, the control group two was treated with methyldopa, and the observation group was treated with nidipine combined with methyldopa. The changes of hemodynamic indexes and micro-inflammatory indexes in three groups were compared. Results After 7 days of treatment, the levels of heart rate(HR)and mean arterial pressure(MAP)in three groups were significantly lower than those before treatment, cardiac output(CO)level was significantly higher than that before treatment, and these indexes in the observation group were significantly better than those in the control group one and the control group two(P< 0.05). The serum levels of high-sensitivity C-reactive protein(hs -CRP), tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in three groups were significantly lower than those before treatment, and those in the observation group were significantly better than the control group one and the control group two(P< 0.05). Conclusion Methyldopa combined with nicardipine has a significant effect for the patients with preeclampsia, which can effectively improve hemodynamic indicators and reduce inflammatory response of the body.