Effect observation of methyldopa combined with nicardipine in treatment of patients with preeclampsia
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摘要: 目的 探讨甲基多巴联合尼卡地平对子痫前期患者血流动力学及微炎症状态的影响。 方法 将91例子痫前期患者根据治疗方式不同分为观察组(n=31)、对照1组(n=30)和对照2组(n=30)。对照1组采用尼卡地平治疗,对照2组采用甲基多巴治疗,观察组采用尼卡地平联合甲基多巴治疗。比较3组血流动力学指标及微炎症状态指标的变化。 结果 治疗7 d后,3组心率(HR)、平均动脉压(MAP)水平均低于治疗前,心排出量(CO)水平高于治疗前,且观察组优于对照1组与对照2组,差异有统计学意义(P<0.05); 3组血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平均低于治疗前,且观察组优于对照1组与对照2组,差异有统计学意义(P<0.05)。 结论 甲基多巴联合尼卡地平对子痫前期患者疗效显著,可有效改善血流动力学指标,减轻机体炎症反应。Abstract: Objective To investigate the effect of methyldopa combined with nicardipine on the hemodynamics and micro-inflammatory state of patients with preeclampsia. Methods A total of 91 patients with preeclampsia were divided into observation group(n=31), control group one(n=30)and control group two(n=30)according to different treatment methods. The control group one was treated with nidipine, the control group two was treated with methyldopa, and the observation group was treated with nidipine combined with methyldopa. The changes of hemodynamic indexes and micro-inflammatory indexes in three groups were compared. Results After 7 days of treatment, the levels of heart rate(HR)and mean arterial pressure(MAP)in three groups were significantly lower than those before treatment, cardiac output(CO)level was significantly higher than that before treatment, and these indexes in the observation group were significantly better than those in the control group one and the control group two(P< 0.05). The serum levels of high-sensitivity C-reactive protein(hs -CRP), tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in three groups were significantly lower than those before treatment, and those in the observation group were significantly better than the control group one and the control group two(P< 0.05). Conclusion Methyldopa combined with nicardipine has a significant effect for the patients with preeclampsia, which can effectively improve hemodynamic indicators and reduce inflammatory response of the body.
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Keywords:
- preeclampsia /
- methyldopa /
- nicardipine /
- hemodynamics /
- micro-inflammatory state
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