Abstract: Objective To analyze the effect of general anesthesia combined with epidural anesthesia in patients with abdominal surgery. Methods A total of 300 patients with abdominal surgery were randomly divided into general anesthesia group(general anesthesia)and combined anesthesia group(general anesthesia combined with epidural anesthesia), with 150 cases in each group. The changes of cognitive function score before anesthesia, 12 and 24 h after anesthesia, induction dose of anesthetics and intraoperative dosage were observed and compared and the incidence of postoperative cognitive dysfunction(POCD)was recorded in the two groups. Results Compared with general anesthesia group, the Mini-mental State Examination(MMSE)scoresof combined anesthesia group were significantly higher at 12 and 24 h after anesthesia(P<0.05). Compared with the general anesthesia group, the maintenance and induction dosage of propofol and fentanyl in the combined anesthesia group were significantly less(P<0.05). There was no significant difference between the two groups in the amount of cisatracurium besylate(P>0.05). Compared with the general anesthesia group, the combined anesthesia group had shorter time of awake eye opening, accurate completion of instructions and pulling out tracheal extubation(P<0.05). The incidence of POCD in the combined anesthesia group was lower than that in the general anesthesia group, and the difference was statistically significant(P<0.05). Conclusion General anesthesia combined with epidural anesthesia can significantly reduce dosage of anesthetics and has little effect on postoperative cognitive function.