Abstract: Objective To compare the efficacy and safety of oxycodone combined with ropivacaine and sufentanyl combined with ropivacaine in epidural labor analgesia. Methods Eighty pregnant women with gestational age ≥37 weeks and single pregnancy were recruited, and were randomly divided into control group and observation group. The control group(n=40)adopted 0.5 μg/mL sufentanil combined with 0.08%ropivacaine for 8 mL for epidural labor analgesia and observation group(n=40)received 0.2 mg/mL oxycodone combined with 0.08%ropivacaine for epidural labor analgesia. The onset time of analgesia, duration of initial analgesia, additional times of analgesia pump, application rate of local anesthetics during suturing in perineotomy, maternal satisfaction and coordination degree, maternal adverse reactions, newborn Apgar score, umbilical arterial blood pH value were compared between the two groups. Results Compared with control group, observation group had a longer analgesia time, a lower incidence of pain outbreak, a less number of additional analgesia pump, a lower rate of additional application of local anesthetics, and a higher degree of satisfaction and coordination among pregnant women(P<0.05). The incidence of hypertension was significantly higher,and incidence of pruritus in the observation group was significantly lower than that in control group(P<0.05). There were no significant differences in Apgar score and pH value of umbilical artery between the two groups(P>0.05). Conclusion Oxycodone combined with ropivacaine for epidural labor analgesia has better effect and duration than sufentanil combined with ropivacaine, and has no adverse effects on neonatal safety.