Advances in exosomes microRNA in chronic kidney disease
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摘要: 慢性肾脏病(CKD)是目前人类重要致死原因之一,发病率逐年升高。部分患者在发现时已是终末期肾衰竭,预后较差,治疗费用较高。因此寻找新型早期诊断慢性肾脏病的生物标志物至关重要。外泌体衍生的微小RNA(miRNAs)可作为诊断CKD、评估CKD预后的敏感生物标志物,也可用于治疗CKD。本文对近年来外泌体miRNA在CKD中的研究进展进行综述,重点探讨不同来源的外泌体miRNA对CKD发生发展的作用机制以及在治疗中的作用,以期为CKD的早期诊断和治疗提供理论依据。Abstract: Chronic kidney disease(CKD)is currently one of the leading causes of death in human, and its incidence rate is increasing year by year. Some patients were found to have end-stage renal failure with poor prognosis and high treatment cost. Therefore, it is very important to find new biomarkers in early diagnosis of chronic kidney disease. Exosome-derived microRNAs(miRNAs)can be used as sensitive biomarkers for the diagnosis and assessment on prognosis of CKD as well as for the treatment of CKD. This paper reviewed the research progress of exosome miRNA in CKD in recent years. The action mechanism of different sources of exosome miRNAs on the occurrence and development of CKD and their roles in treatment were mainly discussed, so as to provide theoretical basis for the early diagnosis and treatment of CKD.
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Keywords:
- chronic kidney disease /
- exosome /
- microRNA /
- biomarker
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