孕期高强度运动对妊娠结局影响的Meta分析

朱雨婷; 陈颖; 王新新; 田苗; 孔祥; 王艳

doi:10.7619/jcmp.20210051

孕期高强度运动对妊娠结局影响的Meta分析

Effect of high-intensity exercise during pregnancy on maternal and neonatal outcomes: A Meta-analysis

摘要

摘要:
目的应用Meta分析评价孕期高强度运动对妊娠结局的影响。
方法计算机检索Cochrane图书馆、PubMed、Embase数据库、中国生物医学（CBM）、中国知网（CNKI）、万方数据库以及维普期刊资源整合服务平台，收集建库至2020年11月20日有关孕期高强度运动的随机对照研究、队列研究，采用RevMan5.3对所得资料进行Meta分析。
结果共纳入17项研究，包括31 747例孕妇，其中随机对照研究7项，队列研究10项。Meta分析显示，高强度运动能够有效降低巨大儿的出生率（OR=0.49，95% CI为0.25~0.94，P=0.03），且不增加低出生体质量儿的出生率（OR=1.10，95% CI为0.86~1.40，P=0.46），提高产后新生儿1、5 min Apgar评分（MD=0.11，95% CI为0.01~0.21，P=0.03；MD=0.11，95% CI为0.01~0.21，P=0.02）。
结论孕期高强度运动在一定程度上是安全的，能够降低部分不良妊娠结局风险，缩短孕妇产后住院时间，但仍需大样本、多中心、高质量的研究来证实其对流产、死产等不良事件的影响。

Abstract:
Objective To evaluate the effect of high-intensity exercise during pregnancy on maternal and neonatal outcomes by a Meta-analysis.
Methods Computer retrieval of the databases such as PubMed, Cochrane Library, Embase, Chinese Biomedical Literature (CBM) database, Chinese National Knowledge Infrastructure (CNKI), Wanfang database and Weipu Journal Resource Integration Service Platform was performed to search randomized controlled studies and cohort studies on high intensity exercise during pregnancy up to November 20, 2020. The statistical analysis was performed by Rev Man5.3.
Results A total of 17 studies were included with 31 747 pregnant women, including 7 randomized controlled studies and 10 cohort studies. The results of Meta-analysis showed that high-intensity exercise was able to effectively reduce the risks of fetal macrosomia (OR=0.49, 95%CI, 0.25 to 0.94, P=0.03) and not increase low birth weight (OR=1.10, 95%CI, 0.86 to 1.40, P=0.46), and increase the 1 and 5 min Apgar scores after birth (MD=0.11, 95%CI, 0.01 to 0.21, P=0.03; MD=0.11, 95%CI was 0.01 to 0.21, P=0.02).
Conclusion High-intensity exercise during pregnancy may be safe to a certain extent, which can reduce some adverse perinatal outcomes and shorten the duration of hospital stays for pregnant women. However, large-scale, multi-center and high-quality studies are still needed to confirm the influence of high-intensity exercise on abortion and stillbirths or other types of adverse events.

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